A0A327ZQJ4 · A0A327ZQJ4_9STAP

  • Protein
    6,7-dimethyl-8-ribityllumazine synthase
  • Gene
    ribH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site215-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site55-575-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site79-815-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site84-85(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)
Active site87Proton donor
Binding site1115-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site125(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentriboflavin synthase complex
Molecular Function6,7-dimethyl-8-ribityllumazine synthase activity
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6,7-dimethyl-8-ribityllumazine synthase
  • EC number
  • Short names
    DMRL synthase
    ; LS
    ; Lumazine synthase

Gene names

    • Name
      ribH
    • ORF names
      BHU61_09695

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 01/688
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Macrococcus

Accessions

  • Primary accession
    A0A327ZQJ4

Proteomes

Subcellular Location

Interaction

Subunit

Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

Family & Domains

Sequence similarities

Belongs to the DMRL synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    154
  • Mass (Da)
    16,455
  • Last updated
    2018-10-10 v1
  • Checksum
    6199C9D9741A7709
MNYSAQLTGQGLKIAVVTSRFNHFITDRLTEGAVDTLERHGVESENIDTFLVPGAFELPFIASKLAQKKKYDAIITLGCVIRGATTHYDYVCNEAAKGIAKAGEYGTPVIFGVVTTETIEQAIERAGTKAGNKGGEAAIGAIEMANLNKMVESI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PZJH01000004
EMBL· GenBank· DDBJ
RAK44416.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp