A0A317CKI1 · A0A317CKI1_9GAMM
- ProteinThiol:disulfide interchange protein DsbD
- GenedsbD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids803 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.
Catalytic activity
- [protein]-dithiol + NAD+ = [protein]-disulfide + H+ + NADH
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | electron transfer activity | |
Molecular Function | protein-disulfide reductase (NAD(P)H) activity | |
Biological Process | cell redox homeostasis | |
Biological Process | cytochrome complex assembly |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThiol:disulfide interchange protein DsbD
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Thiotrichales > Thiotrichaceae > Leucothrix
Accessions
- Primary accessionA0A317CKI1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 376-407 | Helical | ||||
Sequence: ILAVIGLFFLGGLLLTFTPCVFPMIPILSGII | ||||||
Transmembrane | 419-444 | Helical | ||||
Sequence: AFALSLAYVVPMALTYAAAGVIAGYT | ||||||
Transmembrane | 456-476 | Helical | ||||
Sequence: WVLSMFALLFVILSLSMFGFY | ||||||
Transmembrane | 497-530 | Helical | ||||
Sequence: GGSLVGAGIMGVLSALIVGPCVTAPLIAALAYIA | ||||||
Transmembrane | 536-561 | Helical | ||||
Sequence: VLGGLSLFMLGMGMGAPLLVIGVSAG | ||||||
Transmembrane | 573-590 | Helical | ||||
Sequence: TVKHIFGVMMLGLAIWML | ||||||
Transmembrane | 596-616 | Helical | ||||
Sequence: PQITLLLSGILLVGSAIFLGA | ||||||
Transmembrane | 636-657 | Helical | ||||
Sequence: LVSLLLGTILIIGAAAGSKSYF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MRNIMKAFFSVIVLLITTSLYA | ||||||
Chain | PRO_5016472866 | 23-803 | Thiol:disulfide interchange protein DsbD | |||
Sequence: ASDTLLRPSEAFKLTTETIDSQTVRATWTIEEGYYLYRDKIDFISETQDSSVANVFKPAGNPKKDPTFGEVDIYRGVVTFDISLQHNNSNSPQLIQLLSKSQGCADIGLCYPPQKQTVNVKLPPSFSNTATSETPLNNPISPVSLADELGISSITGTSEPDSITGIGGISSIGGNQANEPLPPDEAFRFDIIATDSNTLNARWNVTPGHYLYQHKIGFKVDGNKHNVTLGKPNLPEGKAYKDVYFGDVVTYDKDFEVTVPVSGYNETLEVITEYQGCSELTGICYPPQTKTELVDFSAFPPSTITKAQTGSDASNTTDATTTEKTATPTADTTTITESASQQSALSDALKNKGILAVIGLFFLGGLLLTFTPCVFPMIPILSGIITGQGEDLSRGKAFALSLAYVVPMALTYAAAGVIAGYTGANLQAALQNPWVLSMFALLFVILSLSMFGFYELQMPSAIQNKLNNISNTQRGGSLVGAGIMGVLSALIVGPCVTAPLIAALAYIADTKDVVLGGLSLFMLGMGMGAPLLVIGVSAGSVLPRAGAWMETVKHIFGVMMLGLAIWMLDRIVPPQITLLLSGILLVGSAIFLGATDSLNETSSGWKRLWKSSGLVSLLLGTILIIGAAAGSKSYFAPLSGLLATNSPNNSSDTLAEPTGLQFKKISSLSDLDSTLQLARNTNTPVMLDFYAYWCLPCREMEHTVFSDSDVVATLENTIVIQADVTDMNENDSALLKELEVFGPPHVIFYDRNGEERKDFRISGEMKLEPFKQHIQRFLSNV | ||||||
Disulfide bond | 395↔517 | Redox-active | ||||
Sequence: CVFPMIPILSGIITGQGEDLSRGKAFALSLAYVVPMALTYAAAGVIAGYTGANLQAALQNPWVLSMFALLFVILSLSMFGFYELQMPSAIQNKLNNISNTQRGGSLVGAGIMGVLSALIVGPC | ||||||
Disulfide bond | 716↔719 | Redox-active | ||||
Sequence: CLPC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 327-355 | Disordered | ||||
Sequence: TKAQTGSDASNTTDATTTEKTATPTADTT | ||||||
Domain | 662-801 | Thioredoxin | ||||
Sequence: GLLATNSPNNSSDTLAEPTGLQFKKISSLSDLDSTLQLARNTNTPVMLDFYAYWCLPCREMEHTVFSDSDVVATLENTIVIQADVTDMNENDSALLKELEVFGPPHVIFYDRNGEERKDFRISGEMKLEPFKQHIQRFLS |
Sequence similarities
Belongs to the thioredoxin family. DsbD subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length803
- Mass (Da)86,295
- Last updated2018-10-10 v1
- Checksum9EB98179D8288D35
Keywords
- Technical term