A0A317CJL8 · A0A317CJL8_9GAMM

  • Protein
    Phosphoribosylformylglycinamidine synthase
  • Gene
    purL
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site307-318ATP (UniProtKB | ChEBI)
Binding site678ATP (UniProtKB | ChEBI)
Binding site679Mg2+ (UniProtKB | ChEBI)
Binding site718Mg2+ (UniProtKB | ChEBI)
Binding site722Mg2+ (UniProtKB | ChEBI)
Binding site886Mg2+ (UniProtKB | ChEBI)
Binding site888ATP (UniProtKB | ChEBI)
Active site1137Nucleophile
Active site1262
Active site1264

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase
  • EC number
  • Short names
    FGAM synthase
    ; FGAMS
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase
      (FGAR amidotransferase
      ; FGAR-AT
      )

Gene names

    • Name
      purL
    • ORF names
      DKT75_02765

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • IMCC9719
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Thiotrichales > Thiotrichaceae > Leucothrix

Accessions

  • Primary accession
    A0A317CJL8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain36-150Phosphoribosylformylglycinamidine synthase N-terminal
Domain171-220Phosphoribosylformylglycinamidine synthase linker
Region305-327Disordered
Domain432-586PurM-like C-terminal
Domain648-806FGAR-AT PurM-N-like
Domain859-967PurM-like C-terminal

Sequence similarities

In the N-terminal section; belongs to the FGAMS family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,297
  • Mass (Da)
    140,494
  • Last updated
    2018-10-10 v1
  • MD5 Checksum
    E1FA0EC56AB3F52BDEDC2CC49A9E53EA
MLIIPGGRAFSDFIQSKLLTKLQSDVPVVTAVHARYQHFADVEQYLDVTQLELLENLLSYGEEQDTATPSGELFLVTPRQGTISPWSSKATDILHNCGLTTVSRVERATAYYIESSAALNEDQKALICAELHDRMMESVQFDYSGVDDLFSHAEPAELRFIDLGTDAQTALSDANTELGLALSLDEIDYLADNYAALGRSPTDVELMMFAQANSEHCRHKIFNADWIIDGKPEAETLFGMIRNTYKCSPEGVLTAYSDNSSVIEGPAASRFFPKFGSNEYAHHDEPVHMLMKVETHNHPTAISPFPGAATGSGGEIRDEGATGNGSKPKAGLCGFSVSNLRIPEYEMPWENDFGRPARIDSALNIMLEGPIGAAAFNNEFGRPNLCGYFRSFEAEVPGPKGMELRGYHKPIMLAGGLGNIRPDNVKKKELPEGTPIVVLGGPAMLIGLGGGAASSMASGTSAEKLDFASVQRGNPEMERRCQEVIDRCNALGDDSPLLSMHDVGAGGISNAIPEIIHDAGRGGKFELRSVPNAEPGMAPMEIWCNEAQERYVLAVDETKLAQFEDICQRERAVYAVVGHATEDQHLLVADSNFDNKPVDMPMNVLLGKPPKMLRDVKHVEFTQPEFDYSGIDLAEAIERVLRMPTVASKSFLITIGDRSITGMVNRDQMVGPWQVPVADVAVTATDYKSYTGEAMALGERTPIALVNPAASGRMAIGEAITNIAAANIGELSNMVLSANWMAAAGHDGEDAALYDTVRAVGEEICPKLGICIPVGKDSLSMKTVWQQGDEPREMTSPLSLVVTSFSCVEDIRNTLTPQLRTDKGDTKLMLIDLGKGENRMAASALSQVYSKVGKYAPDFKDTDMMLGFFKAIQTLSAEGKLLAYHDRSDGGLLASVAEMAFAGHTGVSVELDKVAADATQALFNEELGAVIQVKASDLVAVETAFADAGLADYTHVIGQLNDQDTVEFSLAGETVYSNARVTLHQFWSEASYRMQSLRDNTECADQEFERIADAKDTGLFADLSFDVNEDITADLIASGNRPAVAILREQGVNGQIEMAAAFDKAGFRTVDVHMTDVLSGRVSFADFKGLVACGGFSYGDVLGAGGGWAKTILNNEKASQAFSEFFEREDTFALGVCNGCQMLSQLKHMIPGASHWPSFYRNHSEQFEGRVAMVEVTESPSVFLQGMVGSKMPIAVAHGEGRAVFDTEVSIDALVAAQKVALRYVDAQGQATEHYPENPNGSVGGLTGLCSDNGRVTIMMPHPERVQRAVTNSWAPDEWAEDGAWMRMFRNARVWVG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QGKL01000010
EMBL· GenBank· DDBJ
PWQ98748.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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