A0A315ANR8 · A0A315ANR8_9BURK
- ProteinUDP-N-acetylmuramoylalanine--D-glutamate ligase
- GenemurD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids611 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Catalytic activity
- ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H+ + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | tetrahydrofolylpolyglutamate synthase activity | |
Molecular Function | UDP-N-acetylmuramoylalanine-D-glutamate ligase activity | |
Biological Process | cell division | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-N-acetylmuramoylalanine--D-glutamate ligase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Limnohabitans
Accessions
- Primary accessionA0A315ANR8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MQLQGQHVLILGLGASGLAMA | ||||||
Chain | PRO_5016258587 | 22-611 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | |||
Sequence: RWCAHAGANVTVADTREAPPQLAALQAEWPAVRFISGPFAANLIEGSSVRAVFRSPGLAPDVVAPVVDAAQAMGLWQGGELSLFAAGLQDLKNRFGYAPQVLAITGTNGKTTVTSLTGQLVARAGKTVKVAGNIGPTLLDTLTDAIVQAKAQVDQDEAQREAEEAAELAVNPEKNATTAERVAATAPHVAAAVEAETLVSTTDLHTGKTAEDASDEHSDDLGSAAEEEIPVALDGDDAEPLLIAPAPVVSLDPMAQALPQVWVLELSSFQLDSSEGFEPTAATVLNISQDHLDWHGSMDAYAAAKARIFGAQALMVLNREDPLVMAMRPAPVRVKLQKPVERACVTFGGDMPTRPGDYGIEVMNGMTWLVRALEADETRRRRKDEAEELHIQRLMPADALRIRGRHNAVNALAALALAGSAGCALGPMLYGLREYRGEPHRVEPVAIVNEVEYFDDSKGTNVGATVAALQGLGADRRVVVILGGDGKGQDFSPLRDPVSRFARGVVLIGRDGPRMREVLQDSGVPLQDAADMHAAVAQAIRMAHIGDAVLMSPACASFDMFENYGHRAKVFCDAVAELAEAAGVAMEGGV |
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 125-172 | Mur ligase central | ||||
Sequence: ITGTNGKTTVTSLTGQLVARAGKTVKVAGNIGPTLLDTLTDAIVQAKA | ||||||
Coiled coil | 160-189 | |||||
Sequence: LDTLTDAIVQAKAQVDQDEAQREAEEAAEL | ||||||
Domain | 274-439 | Mur ligase central | ||||
Sequence: PMAQALPQVWVLELSSFQLDSSEGFEPTAATVLNISQDHLDWHGSMDAYAAAKARIFGAQALMVLNREDPLVMAMRPAPVRVKLQKPVERACVTFGGDMPTRPGDYGIEVMNGMTWLVRALEADETRRRRKDEAEELHIQRLMPADALRIRGRHNAVNALAALALA | ||||||
Domain | 461-576 | Mur ligase C-terminal | ||||
Sequence: HRVEPVAIVNEVEYFDDSKGTNVGATVAALQGLGADRRVVVILGGDGKGQDFSPLRDPVSRFARGVVLIGRDGPRMREVLQDSGVPLQDAADMHAAVAQAIRMAHIGDAVLMSPAC |
Sequence similarities
Belongs to the MurCDEF family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length611
- Mass (Da)64,398
- Last updated2018-10-10 v1
- Checksum86D929F240B8EF27