A0A2Z6ES53 · A0A2Z6ES53_9BURK

Function

function

Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 divalent ions per subunit.

Pathway

Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site16ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site18Mg2+ (UniProtKB | ChEBI)
Binding site44K+ (UniProtKB | ChEBI)
Binding site57L-methionine (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site100L-methionine (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site167-169ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site233-234ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site242ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site242L-methionine (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site248-249ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site265ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site269ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site273L-methionine (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionmethionine adenosyltransferase activity
Biological Processone-carbon metabolic process
Biological ProcessS-adenosylmethionine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-adenosylmethionine synthase
  • EC number
  • Short names
    AdoMet synthase
  • Alternative names
    • MAT
    • Methionine adenosyltransferase

Gene names

    • Name
      metK
    • ORF names
      MCB1EB_0073

Organism names

  • Taxonomic identifier
  • Strain
    • B1-EB
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Mycoavidus

Accessions

  • Primary accession
    A0A2Z6ES53

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer; dimer of dimers.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region100-110Flexible loop

Sequence similarities

Belongs to the AdoMet synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    392
  • Mass (Da)
    42,266
  • Last updated
    2018-10-10 v1
  • Checksum
    6266960B9F3126E3
MANNYLFTSESVSEGHPDKVADQISDAVLDAILAQDKYARVAAETLCNTGLVVLAGEITTHANIDYIQIARDTIKRIGYDNTDFGIDYRGCAVLVAYDKQSPDIAQGVDNAHDDNFDQGAGDQGLMFGYACNETVELMPLPIHLAHRLVERQASLRHSGQLPWLRPDAKAQVTLRYIDDKPYSIDTVVLSTQHAPEMDLGSLREAVVEEIIKPILPAALLKNKINYLVNPTGRFVIGGPQGDCGLTGRKIIVDTYGGAAPHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLAERCLIQISYAIGVAQPTSVMVNTFGTGRVPDAVITSLVQQYFDLRPKGIIQMLNLLRPIYAKTAAYGHFGRKESGFSWEITDKADALSEAAGIKAVA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP018150
EMBL· GenBank· DDBJ
BBE08234.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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