A0A2Z6EA28 · A0A2Z6EA28_9VERT

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COX1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • KN1
    • Sb01
    • Sb02
    • Sb03
    • Sb04
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Cyclostomata > Myxini > Myxiniformes > Myxinidae > Eptatretinae > Eptatretus

Accessions

  • Primary accession
    A0A2Z6EA28

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane16-37Helical
Transmembrane57-83Helical
Transmembrane148-171Helical
Transmembrane183-210Helical
Transmembrane243-261Helical
Transmembrane268-291Helical
Transmembrane303-326Helical
Transmembrane338-359Helical
Transmembrane379-400Helical
Transmembrane412-430Helical
Transmembrane450-473Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-515Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    516
  • Mass (Da)
    57,865
  • Last updated
    2018-10-10 v1
  • MD5 Checksum
    2310BBEFE2520B6A10CAB9E145D67A7E
MYLSRWLFSTNHKDIGTLYLIFGAWAGMIGTALSVIIRTELSQPGPLINNDQLYNTIITAHAFIMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLSSSMISSGAGTGWTVYPPLSNHISHMGPSVDLTIFSLHLAGVSSILGAINFITTIINMKMQSMTMYHIPLFVWSILITTILLLLSLPVLAAAITMLLTDRNLNTTFFDPSGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVTFYSGKKEPFGYMGMTWAMMAIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATIHGGNIKWEAPMLWAVGFIFLFTVGGLTGIVLSNSSLDVVLHDTYYVVAHFHYVLSMGAVFAIMAGLMHWFPLFSGYSINQTWAKIHFWVMFTGVNLTFFPQHFLGLAGMPRRYSDYPDAYSSWNVLSSMGSMISFMATIILMFIIWEAFSSKRKPLLSNLPLHNPEWLYGTPPIFHTFENPVYLKLSKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP017471
EMBL· GenBank· DDBJ
BAX30180.1
EMBL· GenBank· DDBJ
Genomic DNA
LC178903
EMBL· GenBank· DDBJ
BBE00983.1
EMBL· GenBank· DDBJ
Genomic DNA
LC178904
EMBL· GenBank· DDBJ
BBE00984.1
EMBL· GenBank· DDBJ
Genomic DNA
LC178905
EMBL· GenBank· DDBJ
BBE00985.1
EMBL· GenBank· DDBJ
Genomic DNA
LC178906
EMBL· GenBank· DDBJ
BBE00986.1
EMBL· GenBank· DDBJ
Genomic DNA
LC178907
EMBL· GenBank· DDBJ
BBE00987.1
EMBL· GenBank· DDBJ
Genomic DNA
LC178908
EMBL· GenBank· DDBJ
BBE00988.1
EMBL· GenBank· DDBJ
Genomic DNA
LC178909
EMBL· GenBank· DDBJ
BBE00989.1
EMBL· GenBank· DDBJ
Genomic DNA
LC178910
EMBL· GenBank· DDBJ
BBE00990.1
EMBL· GenBank· DDBJ
Genomic DNA
LC178911
EMBL· GenBank· DDBJ
BBE00991.1
EMBL· GenBank· DDBJ
Genomic DNA
LC178912
EMBL· GenBank· DDBJ
BBE00992.1
EMBL· GenBank· DDBJ
Genomic DNA
LC178913
EMBL· GenBank· DDBJ
BBE00993.1
EMBL· GenBank· DDBJ
Genomic DNA
LC178914
EMBL· GenBank· DDBJ
BBE00994.1
EMBL· GenBank· DDBJ
Genomic DNA
LC178915
EMBL· GenBank· DDBJ
BBE00995.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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