A0A2Z6DYC5 · A0A2Z6DYC5_HYDTE
- ProteinPhosphoribosyl-AMP cyclohydrolase
- GenehisI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids153 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
Catalytic activity
- 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Mg2+ ion per subunit.
Note: Binds 1 zinc ion per subunit.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 102 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 103 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 104 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 106 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 120 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 127 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | magnesium ion binding | |
Molecular Function | phosphoribosyl-AMP cyclohydrolase activity | |
Molecular Function | zinc ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoribosyl-AMP cyclohydrolase
- EC number
- Short namesPRA-CH
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Hydrogenophilia > Hydrogenophilales > Hydrogenophilaceae > Hydrogenophilus
Accessions
- Primary accessionA0A2Z6DYC5
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length153
- Mass (Da)16,685
- Last updated2018-10-10 v1
- MD5 ChecksumB840AD9C6662873BE3CEF6B3997012B7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP018558 EMBL· GenBank· DDBJ | BBD77348.1 EMBL· GenBank· DDBJ | Genomic DNA |