A0A2Z6DW87 · A0A2Z6DW87_HYDTE

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

122320406080100120140160180200220
Type
IDPosition(s)Description
Binding site15-17N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site65(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site90-93(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site107(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site109Proton donor
Site145Raises pKa of active site His

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • ORF names
      HPTL_0442

Organism names

Accessions

  • Primary accession
    A0A2Z6DW87

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-182Formyl transferase N-terminal

Sequence similarities

Belongs to the GART family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    223
  • Mass (Da)
    24,624
  • Last updated
    2018-10-10 v1
  • Checksum
    5395D7BBCF3B777E
MAAEKRLVILISGRGSNMEAIVRAQIPGATVAAVISNRPDAAGLRFAQQHGIATEVVDHKAFPTRDAFDKMLAERIDHYRPDLVVLAGFMRILGEAFVRRYEGRMMNIHPSLLPAFPGLHTHERAIAEGCRVHGATVHFVTPALDHGPIIVQAAVPVLPEDTPETLAARVLREEHRIYPQAIRWFVEGRISLTPEGRVVVAQARFPDTALHVPATTEREEAHI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP018558
EMBL· GenBank· DDBJ
BBD76710.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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