A0A2Z6AQX6 · PVPS_TALVE

Function

function

Bifunctional sesterterpene synthase that possesses both prenyl transferase and terpene cyclase activity, converting isopentenyl diphosphate and dimethylallyl diphosphate into geranylfarnesyl diphosphate (GFPP) and further converting GFPP into preasperterpenoid A.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Secondary metabolite biosynthesis; terpenoid biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site176Mg2+ 1 (UniProtKB | ChEBI)
Binding site176Mg2+ 2 (UniProtKB | ChEBI)
Binding site176substrate
Binding site180Mg2+ 1 (UniProtKB | ChEBI)
Binding site180Mg2+ 2 (UniProtKB | ChEBI)
Binding site266-269substrate
Binding site310substrate
Binding site314-318substrate
Binding site406-407substrate
Binding site499isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site502isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site531isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site538Mg2+ 3 (UniProtKB | ChEBI)
Binding site538Mg2+ 4 (UniProtKB | ChEBI)
Binding site542Mg2+ 3 (UniProtKB | ChEBI)
Binding site542Mg2+ 4 (UniProtKB | ChEBI)
Binding site547dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site548isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site625dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site626dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site662dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site669dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site679dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site689dimethylallyl diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionlyase activity
Molecular Functionmetal ion binding
Molecular Functionprenyltransferase activity
Biological Processalcohol biosynthetic process
Biological Processketone biosynthetic process
Biological Processmycotoxin biosynthetic process
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Preasperterpenoid A synthase PvPS
  • Alternative names
    • Bifunctional sesterterpene synthase PvPS
      (PS
      )

Including 3 domains:

  • Recommended name
    Preasperterpenoid A cyclase
  • EC number
  • Recommended name
    Geranylgeranyl diphosphate synthase
  • EC number
  • Short names
    GGDP synthase
    ; GGS
  • Recommended name
    Geranylfarnesyl diphosphate synthase
  • EC number
  • Short names
    GFDP synthase

Gene names

    • Name
      PvPS

Organism names

Accessions

  • Primary accession
    A0A2Z6AQX6

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004537911-778Preasperterpenoid A synthase PvPS

Interaction

Subunit

Hexamer.

Family & Domains

Features

Showing features for region, motif, compositional bias.

TypeIDPosition(s)Description
Region1-414Terpene cyclase
Motif176-180DDXXD 1
Motif310-318NSE/DTE
Compositional bias414-433Basic and acidic residues
Region415-778Prenyltransferase
Region416-454Disordered
Motif538-542DDXXD 2

Domain

The conserved DDXXD motifs as well as the NSE/DTE motif are important for the catalytic activity, presumably through binding to Mg2+.

Sequence similarities

In the N-terminal section; belongs to the terpene synthase family.
In the C-terminal section; belongs to the FPP/GGPP synthase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    778
  • Mass (Da)
    87,884
  • Last updated
    2018-10-10 v1
  • Checksum
    0485E61AB9C5DC71
MAATKKSTATAAHQIIPSQPTSMSADKFLFSCLQVFVLFFEWARSFLLSTQSRLSAVPAENARLEPSKPISEEEESVIEKPASSITPRYSNLVDPSTYNDLGLCSALPLRVHKFAHLADKGALRAQEDWKRLVGPIRNFTGCLSPRFNGIAVAVPECIPERLEIVTYANEFAFLHDDILDNVGKEEGDHENNEMAAGFGSVLNPADNVKMSASGKSQMQAKLILELLAINEPQAMVLLKCWEGLVKGESGSQHFNFQRLDEYLPHRVINLGQTFWFGIITFAMGLTISPDEAEKANNITDPAYATLALANDYFSWEKEYIEFKQNPTSDDMANAIWIIMKEHSVDLEEAKKICQDKIRESCEEYVRRHRQFEREATGKVSTDLLRYLAALEFSISGNVVWSQYTHRYNFHKPAAKENEDTDDEGAKSDDSKTTLNDSTDSTVVDVKTPATSGLLSSANDVLMSRTAKSLVGPILDVQLPELPDKVVLSPSQYVKSLPSKKVRHHAIDALNIWFNVPEAELEVIKEAIDLLHNSSLMLDDIEDDSPLRRGFPSTHVVYGISQTINSANYLYVMALEMTQRLNSPACLNVFIDELKRLHIGQSLDLYWTANVQCPSLEEYLKMVDYKTGGLFQMVAKLMALKSPMAGRVPDLSNMTTLFGRYFQIRDDYQNLMSEEYTNQKGWCEDLDEGKFSLPLIHSLTTKPNVRLQAMLHQRLINGKMTFEMKKLALDHLAETKSLEYTKEMLGYMYTQLQKEVDFLERQTGSENFLLRLLLKRLQV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias414-433Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC228602
EMBL· GenBank· DDBJ
BBD05405.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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