A0A2Z5ZNL6 · A0A2Z5ZNL6_HPV16

Function

function

Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionnucleotide binding
Biological ProcessDNA replication
Biological ProcessDNA-templated transcription
Biological Processregulation of DNA replication
Biological Processviral DNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Regulatory protein E2

Gene names

    • Name
      E2

Organism names

  • Taxonomic identifier
  • Strains
    • JP1556
    • JPD062
    • JPD071
  • Taxonomic lineage
    Viruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Zurhausenvirales > Papillomaviridae > Firstpapillomavirinae > Alphapapillomavirus > Alphapapillomavirus 9

Accessions

  • Primary accession
    A0A2Z5ZNL6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for cross-link.

TypeIDPosition(s)Description
Cross-link292Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modification

Phosphorylated.
Sumoylation plays a regulatory role in E2 transcriptional activity.

Keywords

Expression

Keywords

Interaction

Subunit

Binds DNA as homodimer. Interacts with protein E1; this interaction greatly increases E1 DNA-binding activity. Interacts with protein L1; this interaction enhances E2-dependent replication and transcription activation. Interacts with protein L2; this interaction inhibits E2 transcriptional activity but not DNA replication function E2. Interacts with protein E7; this interaction inhibits E7 oncogenic activity. Interacts with host TAF1; this interaction modulates E2-dependent transcriptional regulation. Interacts with host BRD4; this interaction mediates E2 transcriptional activation function. Additionally, the interaction with host BRD4 on mitotic chromosomes mediates tethering of the viral genome. Interacts with host TOPBP1; this interaction is required for optimal viral DNA replication.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain1-197Papillomavirus E2 N-terminal
Region1-200Transactivation domain
Region285-365DNA-binding domain
Domain287-363Papillomavirus E2 C-terminal

Sequence similarities

Belongs to the papillomaviridae E2 protein family.
Belongs to the papillomaviridae E8^E2C protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    41,798
  • Last updated
    2018-11-07 v1
  • Checksum
    5E3A7B7D00E826C7
METLCQRLNVCQDKILTHYENDSTDLRDHIDYWKHMRLECAIYYKAREMGFKHINHQVVPTLAVSKNKALQAIELQLTLETIYNSQYSNEKWTLQDVSLEVYLTAPTGCIKKHGYTVEVQFDGDICNTMHYTNWKHIYICEEASVTVVEGQVDYYGLYYVHEGIQTYFVQFKDDAEKYSKNKVWEVHAGGQVILCPTSVFSSNEVSSPETIRQHLANHSAATHTKAVALGTKETQTTIQRPRSEPDTGNPCHTTKLLHRDSVDSAPILTACNSSHKGRINCNSNTTPIVHLKGDANTLKCLRYRFKKHCKLYTAVSSTWHWTGHNVKHKSAIVTLTYDSEWQREQFLSQVKIPKTITVSTGFMSI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB818691
EMBL· GenBank· DDBJ
BAN63253.1
EMBL· GenBank· DDBJ
Genomic DNA
AB889490
EMBL· GenBank· DDBJ
BAO18690.1
EMBL· GenBank· DDBJ
Genomic DNA
AB889493
EMBL· GenBank· DDBJ
BAO18714.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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