A0A2Z5W9R9 · A0A2Z5W9R9_9PLAT

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strain
    • S2
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Rhabditophora > Polycladida > Acotylea > Stylochoidea > Planoceridae > Planocera

Accessions

  • Primary accession
    A0A2Z5W9R9

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane36-58Helical
Transmembrane70-97Helical
Transmembrane130-148Helical
Transmembrane160-178Helical
Transmembrane190-212Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-242Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    242
  • Mass (Da)
    26,156
  • Last updated
    2018-10-10 v1
  • Checksum
    7884087C561FE7DC
LGSFVVEQGVGTGWTIYPPLSGNIAQSGPSVDMAIFSLHLAGVSSILGSINFITTMVNAKVQVTWGQLPLFLWAVMVTAYMLVLSLPVLAGGLTMLLTDRNFNTSFFDPGGGGDPILFQHIFWFFGHPEVYILILPGFGMISQIVTFYSGKDSAFGHMGMVYAILGIGFLGFIVWAHHMYTVGLDIDTRAYFTGATMIIAVPTGIKIFSWLATFYGRPLNQQVDSAGPAWATGFIFLFTLGG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue242

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC341286
EMBL· GenBank· DDBJ
BBB55748.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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