A0A2Z5UXW1 · A0A2Z5UXW1_9EUCA
- ProteinCytochrome b
- GeneCyt b
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids386 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 heme groups non-covalently.
Note: Binds 2 heme groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 92 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 106 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 191 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 205 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 210 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | mitochondrial electron transport, ubiquinol to cytochrome c |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Anomura > Paguroidea > Paguridae > Pagurus
Accessions
- Primary accessionA0A2Z5UXW1
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 39-66 | Helical | ||||
Sequence: FWNFGSLLGLCLVIQILTGLFLSMHYTA | ||||||
Transmembrane | 86-107 | Helical | ||||
Sequence: WLIRSMHANGASFFFVCLYLHI | ||||||
Transmembrane | 119-142 | Helical | ||||
Sequence: IPAWMIGVIILFLVMATAFLGYVL | ||||||
Transmembrane | 148-175 | Helical | ||||
Sequence: SFWGATVITNLFSAIPYVGTYLVNWIWG | ||||||
Transmembrane | 187-208 | Helical | ||||
Sequence: FYSLHFLFPFVVAALSAVHIVF | ||||||
Transmembrane | 238-259 | Helical | ||||
Sequence: IVGFVVMLWALLILSLLFPFAL | ||||||
Transmembrane | 297-317 | Helical | ||||
Sequence: ALGVIALVLSVAALMTFPFTH | ||||||
Transmembrane | 329-349 | Helical | ||||
Sequence: INQWLFWFFISMVIQLTWIGA | ||||||
Transmembrane | 356-381 | Helical | ||||
Sequence: YILTGQILTFLYFSFYIVNPLVLRWW |
Keywords
- Cellular component
Interaction
Subunit
The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-218 | Cytochrome b/b6 N-terminal region profile | ||||
Sequence: MKMPVRKTHPLIKIINGALVDMPLPSNISTFWNFGSLLGLCLVIQILTGLFLSMHYTAHVDLAFSSVAHIHRDVNYGWLIRSMHANGASFFFVCLYLHIGRGIYYGSYVNIPAWMIGVIILFLVMATAFLGYVLPWGQMSFWGATVITNLFSAIPYVGTYLVNWIWGGFAVENATLTRFYSLHFLFPFVVAALSAVHIVFLHQLGAGNPL | ||||||
Domain | 219-386 | Cytochrome b/b6 C-terminal region profile | ||||
Sequence: GISSQVDKVPFHPYFTYKDIVGFVVMLWALLILSLLFPFALMDPDNFIPANPMVTPKHIQPEWYFLFAYAILRSIPNKALGVIALVLSVAALMTFPFTHKSKFKGLTFYPINQWLFWFFISMVIQLTWIGARPVEEPYILTGQILTFLYFSFYIVNPLVLRWWDTKMN |
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length386
- Mass (Da)44,069
- Last updated2018-10-10 v1
- Checksum20612F1CAE2396D9