A0A2Z5U7A9 · A0A2Z5U7A9_PIEBR
- ProteinDystroglycan 1
- Gene01D22_E
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids969 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
function
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoskeleton | |
Cellular Component | dystroglycan complex | |
Cellular Component | extracellular region | |
Cellular Component | nucleoplasm | |
Cellular Component | postsynaptic membrane | |
Cellular Component | sarcolemma | |
Molecular Function | calcium ion binding | |
Molecular Function | laminin binding | |
Biological Process | axon guidance | |
Biological Process | morphogenesis of an epithelium | |
Biological Process | muscle attachment | |
Biological Process | nerve development |
Names & Taxonomy
Protein names
- Recommended nameDystroglycan 1
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Papilionoidea > Pieridae > Pierinae > Pieris
Accessions
- Primary accessionA0A2Z5U7A9
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 804-830 | Helical | ||||
Sequence: YLVTFVIPAVVIVCMILLAGIIACVLY |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 279-301 | Disordered | ||||
Sequence: LPPMSSSETPSTMPETMTSSERT | ||||||
Domain | 426-539 | Peptidase S72 | ||||
Sequence: TINHHFTMQFKLMKPYTNTIDWQIRALEGIVNLFRDTDMDHLTVLNATLIGDICEFVWTNDTLPKDTACPMDDINRLMKILESESEPGSPSAGLARAMSPELKVSAVGWRGLGR | ||||||
Domain | 659-772 | Peptidase S72 | ||||
Sequence: RPTVEFQMTMDPSPNLMETAANKRKIVEKLGALFDQKETENIRIQSITDNPPTIIWYNTSLPMDRCPKREIEELRNSIIVDERGAMGGNLKEKVDQIFDKDLKVMSIRLIPLGL | ||||||
Compositional bias | 867-882 | Basic and acidic residues | ||||
Sequence: ERTDTEPVDKSPVIMR | ||||||
Region | 867-925 | Disordered | ||||
Sequence: ERTDTEPVDKSPVIMREEKPPLLPPAPDYRSGEDAPYRPPPPFAASRTPPRPKATPTYR | ||||||
Compositional bias | 900-925 | Pro residues | ||||
Sequence: DAPYRPPPPFAASRTPPRPKATPTYR |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length969
- Mass (Da)109,131
- Last updated2018-10-10 v1
- Checksum64D6E138DF3C39CB
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: V | ||||||
Compositional bias | 867-882 | Basic and acidic residues | ||||
Sequence: ERTDTEPVDKSPVIMR | ||||||
Compositional bias | 900-925 | Pro residues | ||||
Sequence: DAPYRPPPPFAASRTPPRPKATPTYR |