A0A2Z5JSU1 · A0A2Z5JSU1_9ACTN

  • Protein
    NAD-dependent protein deacetylase
  • Gene
    cobB1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site39-59NAD+ (UniProtKB | ChEBI)
Binding site117-120NAD+ (UniProtKB | ChEBI)
Active site135Proton acceptor
Binding site143Zn2+ (UniProtKB | ChEBI)
Binding site146Zn2+ (UniProtKB | ChEBI)
Binding site194Zn2+ (UniProtKB | ChEBI)
Binding site197Zn2+ (UniProtKB | ChEBI)
Binding site234-236NAD+ (UniProtKB | ChEBI)
Binding site278NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent protein lysine deacetylase activity
Molecular Functiontransferase activity
Molecular Functionzinc ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacetylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog

Gene names

    • Name
      cobB1
    • Synonyms
      cobB
    • ORF names
      C1703_00135

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Go-475
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A2Z5JSU1

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-292Deacetylase sirtuin-type

Sequence similarities

Belongs to the sirtuin family. Class II subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    301
  • Mass (Da)
    31,894
  • Last updated
    2018-10-10 v1
  • Checksum
    E351C9E9D7F137B3
MRMRPTLSWTPAEDLPPGTTDLEPVADALGTGGVLVLSGAGLSTESGIPDYRGEGGSLSRHTPMTYQDFVGGAQARRRYWARSHLGWRTFGRAVPNAGHRAVAAFERHGLLAGVITQNVDGLHQAAGSEDVVELHGALDRVVCLSCGARSPRRELARRLEEANPGFEPVAAGINPDGDADLTDDQVAGFRVVPCTVCGGILKPDVVFFGETVPPQRVEHCRELVRAASSLLVLGSSLTVMSGLRFVRQAAQAGKPVLIVNRDPTRGDRHALTRVALPLGTALTTVADRLGIAVDRQAPPSP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP026121
EMBL· GenBank· DDBJ
AXE83379.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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