A0A2Z4UXD9 · A0A2Z4UXD9_9ACTN
- Protein4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
- GeneispE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids772 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Catalytic activity
- 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H+
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | pyridoxal phosphate binding | |
Molecular Function | transaminase activity | |
Biological Process | antibiotic biosynthetic process | |
Biological Process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway | |
Biological Process | polysaccharide biosynthetic process | |
Biological Process | terpenoid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
- EC number
- Short namesCMK
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionA0A2Z4UXD9
Proteomes
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-53 | Disordered | ||||
Sequence: MDAAADSRHQGSGGTDSASAPPIGRRPSGRRRSAGTPFDTGSSHVDDRDLGRR | ||||||
Domain | 141-199 | GHMP kinase N-terminal | ||||
Sequence: HLHIDKRIPVAGGMAGGSADAAAAIVGCAALWGLDPKDPLLAEVAAEVGSDVAFALMGG | ||||||
Domain | 263-338 | GHMP kinase C-terminal | ||||
Sequence: AAALASGDPDRLAALLRNDLEGAALRLRPELADTLGAGLDAGALGALVSGSGPTCAFLVRDEAAAGTVAAALEASG |
Sequence similarities
Belongs to the DegT/DnrJ/EryC1 family.
Belongs to the GHMP kinase family. IspE subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length772
- Mass (Da)80,186
- Last updated2018-10-10 v1
- Checksum1EDF1B618013BEFF
Keywords
- Technical term