A0A2Z4UXD9 · A0A2Z4UXD9_9ACTN

  • Protein
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
  • Gene
    ispE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

Catalytic activity

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.

Features

Showing features for active site, binding site.

1772100200300400500600700
TypeIDPosition(s)Description
Active site64
Binding site149-159ATP (UniProtKB | ChEBI)
Active site191

GO annotations

AspectTerm
Molecular Function4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
Molecular FunctionATP binding
Molecular Functionpyridoxal phosphate binding
Molecular Functiontransaminase activity
Biological Processantibiotic biosynthetic process
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processpolysaccharide biosynthetic process
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
  • EC number
  • Short names
    CMK
  • Alternative names
    • 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Gene names

    • Name
      ispE
    • ORF names
      DRB96_16045

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ICC1
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A2Z4UXD9

Proteomes

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-53Disordered
Domain141-199GHMP kinase N-terminal
Domain263-338GHMP kinase C-terminal

Sequence similarities

Belongs to the DegT/DnrJ/EryC1 family.
Belongs to the GHMP kinase family. IspE subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    772
  • Mass (Da)
    80,186
  • Last updated
    2018-10-10 v1
  • Checksum
    1EDF1B618013BEFF
MDAAADSRHQGSGGTDSASAPPIGRRPSGRRRSAGTPFDTGSSHVDDRDLGRRTVSVTVQVPAKVNLHLAVGGTRPDGYHELVSVFQAVSLHDTVTATPAPELSVTLEGEDIGAVPADRRNLAAAAAALLAERIGVDPGVHLHIDKRIPVAGGMAGGSADAAAAIVGCAALWGLDPKDPLLAEVAAEVGSDVAFALMGGTAVGTGRGERLTALPDSGRFHWVFAEARGGLSTPRVFREYDLLLAESDTAAPAPAELAPAPDFAAALASGDPDRLAALLRNDLEGAALRLRPELADTLGAGLDAGALGALVSGSGPTCAFLVRDEAAAGTVAAALEASGHCRSVRTAHGPVDGPAARVTTGTDRSSLNVSQGAAVKSVEVPAEPGGREHPGVPFFTQAATFDALWPSISAHVQDVFDRNKWSHGRKCLEFERAVAAYTGAKHAIAVNNGTDALVILLRAAGVRRGDEVVVPAFTFAATATTVAAIGAVPVFADIDPVTYAMDPLSFEKAITERTRAVMPAHLFTQLADMDAISEIADRHGITVLEDSAEGIGMRWNGKHAGLLGRGGVLSFFPTKTLGAIGDAGMILTDDDEVAETAQILRHHGRMGKTIDHIAGISNLSGASGTNSKMDDIQAAVLMAKLPRLDEDIAARARLAQAYHERLSGLPGILRLPTVVERAVPTDAVFYVYEIEVERRDELVAHLASRGIGTETYYPIPLHVQPCFAHLGYGPGDFPVAEAACASAVALPFYPDLTGEQLDTVVAAIRDFFTGSQS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP030287
EMBL· GenBank· DDBJ
AWZ13564.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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