A0A2Z4LZ57 · A0A2Z4LZ57_SPAAU
- ProteinO-acyltransferase
- GeneLOC115578741
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids524 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2OThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- 13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
- 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
- hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoateThis reaction proceeds in the forward direction.
- hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoAThis reaction proceeds in the forward direction.
- hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; glycerolipid metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 454 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | diacylglycerol O-acyltransferase activity | |
Molecular Function | retinol O-fatty-acyltransferase activity | |
Biological Process | triglyceride biosynthetic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameO-acyltransferase
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Spariformes > Sparidae > Sparus
Accessions
- Primary accessionA0A2Z4LZ57
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 118-139 | Helical | ||||
Sequence: ILNWCVVMLVLSNARLFLENII | ||||||
Transmembrane | 159-180 | Helical | ||||
Sequence: YSWPAACLIIVSNVFILAALYT | ||||||
Transmembrane | 192-216 | Helical | ||||
Sequence: MTGLILHMFNLTSLLIFPSATVLSV | ||||||
Transmembrane | 222-239 | Helical | ||||
Sequence: VGGVLSLGVYTVLFLKLY | ||||||
Transmembrane | 321-340 | Helical | ||||
Sequence: LFEMLFFTQLLVGLIQQWMV | ||||||
Transmembrane | 362-381 | Helical | ||||
Sequence: LLKLAVPNHLIWLIFFYWFF | ||||||
Transmembrane | 436-453 | Helical | ||||
Sequence: GINKFCAQTAVFLVSAFF | ||||||
Transmembrane | 465-483 | Helical | ||||
Sequence: FRLWAFMGMMAQVPLAWFV | ||||||
Transmembrane | 495-513 | Helical | ||||
Sequence: AVWISLIIGQPVAVLMYVH |
Keywords
- Cellular component
Interaction
Subunit
Homodimer or homotetramer; both forms have similar enzymatic activities.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-87 | Disordered | ||||
Sequence: MSDRAEMRGPVTRRRRTTISGGGNGAIGVKQASGSKSHEAGEKPPLCPAKAKKDEVDRHASNNGKVDKQMRVSGEQQLANTPRKQRS | ||||||
Compositional bias | 43-65 | Basic and acidic residues | ||||
Sequence: KPPLCPAKAKKDEVDRHASNNGK | ||||||
Compositional bias | 66-86 | Polar residues | ||||
Sequence: VDKQMRVSGEQQLANTPRKQR |
Sequence similarities
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length524
- Mass (Da)60,244
- Last updated2018-10-10 v1
- ChecksumB5E8B8668A88E1DC
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A671W6W7 | A0A671W6W7_SPAAU | LOC115578741 | 440 | ||
A0A671W4Z0 | A0A671W4Z0_SPAAU | LOC115578741 | 444 | ||
A0A671W3J6 | A0A671W3J6_SPAAU | LOC115578741 | 496 | ||
A0A671W3L4 | A0A671W3L4_SPAAU | LOC115578741 | 419 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 43-65 | Basic and acidic residues | ||||
Sequence: KPPLCPAKAKKDEVDRHASNNGK | ||||||
Compositional bias | 66-86 | Polar residues | ||||
Sequence: VDKQMRVSGEQQLANTPRKQR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MG570176 EMBL· GenBank· DDBJ | AWX49624.1 EMBL· GenBank· DDBJ | mRNA |