A0A2Z4LZ32 · A0A2Z4LZ32_SPAAU
- ProteinProstaglandin G/H synthase 2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids608 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
Cofactor
Pathway
Lipid metabolism; prostaglandin biosynthesis.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | neuron projection | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | |
Molecular Function | peroxidase activity | |
Molecular Function | prostaglandin-endoperoxide synthase activity | |
Biological Process | cyclooxygenase pathway | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProstaglandin G/H synthase 2
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Spariformes > Sparidae > Sparus
Accessions
- Primary accessionA0A2Z4LZ32
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Peripheral membrane protein
Microsome membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MNRLTFAVFLSALGFLVCEA | ||||||
Chain | PRO_5016450999 | 21-608 | Prostaglandin G/H synthase 2 | |||
Sequence: GNPCCSEPCQNRGVCTALGADNYECDCTRTGYTGQNCTTPEFLTWLKISLKPSPNTVHYILTHFKGFWNIINNISFLRDAIMRYVLTSRSHLIDSPPTFNADYDYKCWEAYSNLSYYTRTLPPVPKDCPTPMGVEGKKELPDAKILAEKLLMRREFIPDPQGTSLMFAFFAQHFTHQFFKSDMKKGPAFTVAQGHGVDLSHIYGDNLVRQHKLRLFKDGKLRHQILDGEMYPPTVKEVGAEMHYPPHVPDSHRFAVGHEAFGLVPGLMMYATIWLREHNRVCDVLKEVHPDWDDERLFQTTRLILIGETIKIVIEDYVQHLSGYNFKLKFDPELLFNQRFQYQNRIASEFNTLYHWHPLMPDTFHIEEKEYNYKQFVFNTSVVTEHGISNLVESFSKQIAGRVAGGRNVPGPIMYVAIKSIENSRQMRYQSLNAYRKRFSMKPYSSFEDMTGEKEMAAVLEEMYGHIDAVELYPGLLVEKPRENAIFGETMVEMGAPFSLKGLMGNPICSPEYWKPSTFGGTVGFDIINTASLQRLVCNNVKGPCPVASFHVPDVKETGSVIINSSTSHSGGSDINPTVILKERTTEL |
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 20-58 | EGF-like | ||||
Sequence: AGNPCCSEPCQNRGVCTALGADNYECDCTRTGYTGQNCT |
Sequence similarities
Belongs to the prostaglandin G/H synthase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length608
- Mass (Da)69,169
- Last updated2018-10-10 v1
- ChecksumC4DF7DE61EFFE8C6