A0A2Z4LZ32 · A0A2Z4LZ32_SPAAU

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Pathway

Lipid metabolism; prostaglandin biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site109substrate
Active site196Proton acceptor
Active site374For cyclooxygenase activity
Binding site377Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentneuron projection
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Molecular Functionperoxidase activity
Molecular Functionprostaglandin-endoperoxide synthase activity
Biological Processcyclooxygenase pathway
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin G/H synthase 2
  • EC number
  • Alternative names
    • Cyclooxygenase-2
    • PHS II
    • Prostaglandin H2 synthase 2
    • Prostaglandin-endoperoxide synthase 2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Spariformes > Sparidae > Sparus

Accessions

  • Primary accession
    A0A2Z4LZ32

Subcellular Location

Endoplasmic reticulum membrane
; Peripheral membrane protein
Microsome membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_501645099921-608Prostaglandin G/H synthase 2

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-58EGF-like

Sequence similarities

Belongs to the prostaglandin G/H synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    608
  • Mass (Da)
    69,169
  • Last updated
    2018-10-10 v1
  • Checksum
    C4DF7DE61EFFE8C6
MNRLTFAVFLSALGFLVCEAGNPCCSEPCQNRGVCTALGADNYECDCTRTGYTGQNCTTPEFLTWLKISLKPSPNTVHYILTHFKGFWNIINNISFLRDAIMRYVLTSRSHLIDSPPTFNADYDYKCWEAYSNLSYYTRTLPPVPKDCPTPMGVEGKKELPDAKILAEKLLMRREFIPDPQGTSLMFAFFAQHFTHQFFKSDMKKGPAFTVAQGHGVDLSHIYGDNLVRQHKLRLFKDGKLRHQILDGEMYPPTVKEVGAEMHYPPHVPDSHRFAVGHEAFGLVPGLMMYATIWLREHNRVCDVLKEVHPDWDDERLFQTTRLILIGETIKIVIEDYVQHLSGYNFKLKFDPELLFNQRFQYQNRIASEFNTLYHWHPLMPDTFHIEEKEYNYKQFVFNTSVVTEHGISNLVESFSKQIAGRVAGGRNVPGPIMYVAIKSIENSRQMRYQSLNAYRKRFSMKPYSSFEDMTGEKEMAAVLEEMYGHIDAVELYPGLLVEKPRENAIFGETMVEMGAPFSLKGLMGNPICSPEYWKPSTFGGTVGFDIINTASLQRLVCNNVKGPCPVASFHVPDVKETGSVIINSSTSHSGGSDINPTVILKERTTEL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG570172
EMBL· GenBank· DDBJ
AWX49620.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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