A0A2Z4I2Y0 · A0A2Z4I2Y0_9VIRU

  • Protein
    Non-structural protein 1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    2/5

Function

function

Multifunctional protein which displays endonuclease and helicase activities required for initiating and directing viral DNA replication. Also plays a role in viral packaging and transactivation of several promoters. Binds site-specifically to 2-3 approximate tandem copies within the origins of replication (Ori), unwinds this hairpin region and nicks one DNA strand thereby initiating the rolling circle replication (RCR). Becomes covalently attached to the 5' end of the nick and provides a 3'OH for priming DNA synthesis. The helicase activity unwinds DNA in a 3'-5' direction on the longer strand. Participates in the transcriptional regulation of several promoters.

Features

Showing features for active site.

166750100150200250300350400450500550600650
TypeIDPosition(s)Description
Active site228For nuclease activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleus
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Biological ProcessDNA replication
Biological Processviral genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Non-structural protein 1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HN13
  • Taxonomic lineage
    Viruses > Monodnaviria > Shotokuvirae > Cossaviricota > Quintoviricetes > Piccovirales > Parvoviridae > Parvovirinae > Bocaparvovirus

Accessions

  • Primary accession
    A0A2Z4I2Y0

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homooligomer; when bound to DNA.

Family & Domains

Features

Showing features for domain, motif, region, compositional bias.

TypeIDPosition(s)Description
Domain24-287PV NS1-Nuc
Motif133-135RCR-2
Motif228-232RCR-3
Domain402-569SF3 helicase
Region638-667Disordered
Compositional bias645-659Basic and acidic residues

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    667
  • Mass (Da)
    76,254
  • Last updated
    2018-10-10 v1
  • Checksum
    C49FA6177413F974
MASAGVGLSDQEWINYWHGAITGFKSPCYTYVIHLDLQDWRPHERALMDIYSKDVSVIIDDIVDTEKEFLLSDVNYEWKASLAMKLQNHHGLGQTLCESADIAVRRLFQLKQQNHNPQYSCFTQAEIGPSKIHVHVVCGGDGLTRFNAKKCTWIIAKFFWNHMLELWEHFESCYRPTNAQMAIGVQLRMLCERIKSKQDTTVTILTYKDRHNEQHAQRVDGPSYITNYLLPKNRQLVTWLDMDVCTPSVAWFETEKTYMCSHIDRQPITHYLRKGLHDRLVMNSSEETGEPVHKMARWGELPQVGENSLARENTRPRPAKITKKQCVMIDTLQRCEDEHICTKEELTMLHPDLVIMFESSPGGSRTLDEVLEMHRVRVTRSYSALGYILKQYPENKFIKPENKVVRLLNIQGYNPIQVGHWVATVLSKKAGKQNTLCFYGPASTGKTNLAKAIVSAVKVYGCVNHLNKNFVFNDCQSKLIAWWEECVMHNDWVEPAKCLMGGTTFRVDRKHKDSAEQPHTPLIISTNHDIYTVVGGNTVTTVHEKPIRDRVVQFNFMKTLPQNFGEISVSDVADWLGWCAEDFDCSLDGFKKEWDIDVVPNSFPLAVYCDGHFQDFLFSAQGPCCRCGGYLPHTTTSDGDWTESADPGRTTRMRERETPSGGDGIIS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias645-659Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MF590244
EMBL· GenBank· DDBJ
AWW25132.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp