A0A2Z2DVB6 · A0A2Z2DVB6_ZIKV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3423 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1553 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: H | ||||||
Active site | 1577 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: D | ||||||
Active site | 1637 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: S | ||||||
Binding site | 2576 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 2606 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 2607 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 2624 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 2625 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 2651 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 2652 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 2740 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 2959 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 2963 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 2968 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2971 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3234 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 3250 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3369 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus zikaense
- Virus hosts
Accessions
- Primary accessionA0A2Z2DVB6
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 746-767 | Helical | ||||
Sequence: LFGGMSWFSQILIGTLLMWLGL | ||||||
Transmembrane | 773-798 | Helical | ||||
Sequence: SISLMCLALGGVLIFLSTAVSADVGC | ||||||
Transmembrane | 1178-1197 | Helical | ||||
Sequence: IIISTSMAVLVAMILGGFSM | ||||||
Transmembrane | 1273-1290 | Helical | ||||
Sequence: VLINGFALAWLAIRAMVV | ||||||
Transmembrane | 1343-1366 | Helical | ||||
Sequence: FVMALGLTAVRLVDPINVVGLLLL | ||||||
Transmembrane | 1378-1394 | Helical | ||||
Sequence: EVLTAVGLICALAGGFA | ||||||
Transmembrane | 1400-1417 | Helical | ||||
Sequence: MAGPMAAVGLLIVSYVVS | ||||||
Transmembrane | 1473-1496 | Helical | ||||
Sequence: VVLMTICGMNPIAIPFAAGAWYVY | ||||||
Transmembrane | 2174-2192 | Helical | ||||
Sequence: IMLLGLLGTVSLGIFFVLM | ||||||
Transmembrane | 2199-2216 | Helical | ||||
Sequence: KMGFGMVTLGASAWLMWL | ||||||
Transmembrane | 2222-2241 | Helical | ||||
Sequence: ARIACVLIVVFLLLVVLIPE | ||||||
Transmembrane | 2253-2275 | Helical | ||||
Sequence: MAIIIMVAVGLLGLITANELGWL | ||||||
Transmembrane | 2306-2327 | Helical | ||||
Sequence: ASAWAIYAALTTFITPAVQHAV | ||||||
Transmembrane | 2334-2353 | Helical | ||||
Sequence: YSLMAMATQAGVLFGMGKGM | ||||||
Transmembrane | 2373-2392 | Helical | ||||
Sequence: LTPLTLIVAIILLVAHYMYL | ||||||
Transmembrane | 2442-2462 | Helical | ||||
Sequence: VLLIAVAVSSAILSRTAWGWG |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 293↔320 | |||||
Sequence: CIGVSNRDFVEGMSGGTWVDVVLEHGGC | ||||||
Disulfide bond | 350↔406 | |||||
Sequence: CYEASISDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTC | ||||||
Disulfide bond | 364↔395 | |||||
Sequence: CPTQGEAYLDKQSDTQYVCKRTLVDRGWGNGC | ||||||
Disulfide bond | 382↔411 | |||||
Sequence: CKRTLVDRGWGNGCGLFGKGSLVTCAKFAC | ||||||
Disulfide bond | 480↔581 | |||||
Sequence: CEPRTGLDFSDLYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKEALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGAKGRLSSGHLKC | ||||||
Disulfide bond | 598↔629 | |||||
Sequence: CTAAFTFTKIPAETLHGTVTVEVQYAGTDGPC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1373-1502 | Flavivirus NS2B | ||||
Sequence: SWPPSEVLTAVGLICALAGGFAKADIEMAGPMAAVGLLIVSYVVSGKSVDMYIERAGDITWEKDAEVTGNSPRLDVALDESGDFSLVEDDGPPMREIILKVVLMTICGMNPIAIPFAAGAWYVYVKTGKR | ||||||
Domain | 1503-1680 | Peptidase S7 | ||||
Sequence: SGALWDVPAPKEVKKGETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGSALRSGEGRLDPYWGDVKQDLVSYCGPWKLDAAWDGHSEVQLLAVPPGERARNIQTLPGIFKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAITQGRREEETPVEC | ||||||
Domain | 1683-1839 | Helicase ATP-binding | ||||
Sequence: PSMLKKKQLTVLDLHPGAGKTRRVLPEIVREAIKTRLRTVILAPTRVVAAEMEEALRGLPVRYMTTAVNVTHSGTEIVDLMCHATFTSRLLQPIRVPNYNLYIMDEAHFTDPSSIAARGYISTRVEMGEAAAIFMTATPPGTRDAFPDSNSPIMDTE | ||||||
Domain | 1834-2013 | Helicase C-terminal | ||||
Sequence: PIMDTEVEVPERAWSSGFDWVTDHSGKTVWFVPSVRNGNEIAACLTKAGKRVIQLSRKTFETEFQKTKHQEWDFVVTTDISEMGANFKADRVIDSRRCLKPVILDGERVILAGPMPVTHASAAQRRGRIGRNPNKPGDEYLYGGGCAETDEDHAHWLEARMLLDNIYLQDGLIASLYRPE | ||||||
Domain | 2521-2785 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: GGGTGETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGHAVSRGSAKLRWLVERGYLQPYGKVIDLGCGRGGWSYYAATIRKVQEVKGYTKGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYGGGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKYEEDVNLGSGTRA | ||||||
Domain | 3049-3199 | RdRp catalytic | ||||
Sequence: GRMYADDTAGWDTRISRFDLENEALITNQMEKGHRALALAIIKYTYQNKVVKVLRPAEKGKTVMDIISRQDQRGSGQVVTYALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRRSEKVTNWLQSNGWDRLKRMAVSGDDCVVKPIDDRFAHA |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,423
- Mass (Da)379,126
- Last updated2018-10-10 v1
- Checksum58AFE7E6B891540A