A0A2Z2CDH6 · A0A2Z2CDH6_SINWO

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A0A2Z2CDH6

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane46-72Helical
Transmembrane84-102Helical
Transmembrane122-146Helical
Transmembrane167-194Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_503333937619-205Cytochrome c oxidase subunit 1

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-205Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    205
  • Mass (Da)
    21,758
  • Last updated
    2018-10-10 v1
  • Checksum
    BB5434D4F6212EB4
TLYLLLALWSGLIGLALSLLIRAELGQPGSLLGDDQLYNVIVTAHAFMMIFFLVMPMMIGGFGNWLIPLMIGAPDMAFPRLNNLSFWLLVPALFLLLSSSLVESGVGTGWTVYPPLSGNVAHSGASVDLAIFSLHLAGASSILGAINFISTVGNMRSPGLVAERIPLFVWAVTVTAVLLVAALPVLAGAITMLLTDRNLNTSFFD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue205

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KX051315
EMBL· GenBank· DDBJ
AOX13565.1
EMBL· GenBank· DDBJ
Genomic DNA
KX051316
EMBL· GenBank· DDBJ
AOX13566.1
EMBL· GenBank· DDBJ
Genomic DNA
KX051317
EMBL· GenBank· DDBJ
AOX13567.1
EMBL· GenBank· DDBJ
Genomic DNA
KX051319
EMBL· GenBank· DDBJ
AOX13569.1
EMBL· GenBank· DDBJ
Genomic DNA
KX051322
EMBL· GenBank· DDBJ
AOX13572.1
EMBL· GenBank· DDBJ
Genomic DNA
KX051324
EMBL· GenBank· DDBJ
AOX13574.1
EMBL· GenBank· DDBJ
Genomic DNA
KX051325
EMBL· GenBank· DDBJ
AOX13575.1
EMBL· GenBank· DDBJ
Genomic DNA
KX051326
EMBL· GenBank· DDBJ
AOX13576.1
EMBL· GenBank· DDBJ
Genomic DNA
KX051328
EMBL· GenBank· DDBJ
AOX13578.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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