A0A2Y9TF80 · A0A2Y9TF80_PHYMC
- ProteinMediator of RNA polymerase II transcription subunit 25
- GeneMED25
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids795 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | core mediator complex | |
Cellular Component | mediator complex | |
Cellular Component | nucleoplasm | |
Molecular Function | nuclear retinoid X receptor binding | |
Molecular Function | transcription coactivator binding | |
Biological Process | negative regulation of fibroblast proliferation | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of mediator complex assembly | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMediator of RNA polymerase II transcription subunit 25
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Physeteridae > Physeter
Accessions
- Primary accessionA0A2Y9TF80
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 15-226 | Mediator of RNA polymerase II transcription subunit 25 von Willebrand factor type A | |||
Region | 233-273 | Disordered | |||
Domain | 234-383 | Mediator complex subunit Med25 synapsin 1 | |||
Compositional bias | 239-255 | Pro residues | |||
Region | 299-392 | Disordered | |||
Compositional bias | 320-345 | Pro residues | |||
Domain | 397-546 | Mediator complex subunit Med25 PTOV | |||
Region | 548-721 | Disordered | |||
Compositional bias | 575-607 | Polar residues | |||
Compositional bias | 609-636 | Pro residues | |||
Compositional bias | 647-705 | Pro residues | |||
Domain | 729-789 | SPIN-DOC-like zinc-finger | |||
Sequence similarities
Belongs to the Mediator complex subunit 25 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length795
- Mass (Da)84,631
- Last updated2018-09-12 v1
- MD5 Checksum657E1EB11E4BBB1638557B0F0062CE53
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2Y9TD69 | A0A2Y9TD69_PHYMC | MED25 | 746 | ||
A0A2Y9TIJ3 | A0A2Y9TIJ3_PHYMC | MED25 | 706 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 239-255 | Pro residues | |||
Compositional bias | 320-345 | Pro residues | |||
Compositional bias | 575-607 | Polar residues | |||
Compositional bias | 609-636 | Pro residues | |||
Compositional bias | 647-705 | Pro residues | |||
Keywords
- Technical term