A0A2Y9LBW4 · A0A2Y9LBW4_ENHLU
- ProteinBifunctional arginine demethylase and lysyl-hydroxylase JMJD6
- GeneLOC111160293
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids380 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate
- 2-oxoglutarate + L-lysyl-[protein] + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate
- 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate
- 2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 = a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H+ + succinate
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | histone H4R3 demethylase activity | |
Molecular Function | P-TEFb complex binding | |
Biological Process | phagocytosis |
Names & Taxonomy
Protein names
- Recommended nameBifunctional arginine demethylase and lysyl-hydroxylase JMJD6
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Musteloidea > Mustelidae > Lutrinae > Enhydra
Accessions
- Primary accessionA0A2Y9LBW4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 141-305 | JmjC | ||||
Sequence: PKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTREEGGNQQDEAITWFSIIHPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGR |
Sequence similarities
Belongs to the JMJD6 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length380
- Mass (Da)43,863
- Last updated2018-09-12 v1
- Checksum17DB7ACF7E8B423A
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2Y9KXZ9 | A0A2Y9KXZ9_ENHLU | LOC111160293 | 414 | ||
A0A2Y9KZ61 | A0A2Y9KZ61_ENHLU | LOC111160293 | 420 |
Keywords
- Technical term