A0A2Y9G1Q0 · A0A2Y9G1Q0_TRIMA

Function

function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentnuclear inner membrane
Molecular Functiondelta14-sterol reductase activity
Biological Processcholesterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta(14)-sterol reductase TM7SF2
  • EC number
  • Short names
    Delta-14-SR
  • Alternative names
    • 3-beta-hydroxysterol Delta (14)-reductase
    • C-14 sterol reductase
    • Sterol C14-reductase
    • Transmembrane 7 superfamily member 2

Gene names

    • Name
      TM7SF2

Organism names

Accessions

  • Primary accession
    A0A2Y9G1Q0

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-36Helical
Transmembrane56-78Helical
Transmembrane99-122Helical
Transmembrane128-149Helical
Transmembrane327-348Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    390
  • Mass (Da)
    43,093
  • Last updated
    2018-09-12 v1
  • Checksum
    16575E7656C64512
MAPHGPRAPLEFGGPLGAAALMLLLPATMFYLLLVARSGPARLLGPPPYLPGLQALWSPRALLLCLAWLGLQAALYLLPARKVAEGQELKDKSRLQYPINGFQALVLTALLAGLGVLAGLPLAALPEMLLPLAFAATLIAFVFSLLLYLKSQVAPASALAPGGSSGNPIYDFFMGRELNPRICFLDFKYFCELRPGLIGWVLINLALLVQEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLVFGDLAWVPFTYSLQAQFLVHHPQALGLPMASTICLINDLETISTATGRQLLVSGWWGMVRHPNYLGDLIMALAWSLPCGASHLLPYFYLLYFTSLLVHREAHDERQCLQKYGLAWHEYCRRVPYRIVPYIY

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2Y9E0A0A0A2Y9E0A0_TRIMATM7SF2417

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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