A0A2Y9EXA5 · A0A2Y9EXA5_PHYMC
- Protein11-beta-hydroxysteroid dehydrogenase 1
- GeneHSD11B1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids294 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
Catalytic activity
- 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP+ = 3beta-hydroxy-5-androstene-7,17-dione + H+ + NADPHThis reaction proceeds in the forward direction.
- 3beta-hydroxy-5-androstene-7,17-dione + H+ + NADPH = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP+This reaction proceeds in the forward direction.
- 3beta-hydroxy-5alpha-androstane-7,17-dione + H+ + NADPH = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP+This reaction proceeds in the forward direction.
- 7-oxocholesterol + H+ + NADPH = 7beta-hydroxycholesterol + NADP+This reaction proceeds in the forward direction.
- 7-oxolithocholate + H+ + NADPH = NADP+ + ursodeoxycholateThis reaction proceeds in the forward direction.
- 7-oxopregnenolone + H+ + NADPH = 7beta-hydroxypregnenolone + NADP+This reaction proceeds in the forward direction.
- NADP+ + taurochenodeoxycholate = 7-oxotaurolithocholate + H+ + NADPHThis reaction proceeds in the backward direction.
- NADP+ + tauroursodeoxycholate = 7-oxotaurolithocholate + H+ + NADPHThis reaction proceeds in the backward direction.
- chenodeoxycholate + NADP+ = 7-oxolithocholate + H+ + NADPHThis reaction proceeds in the backward direction.
- corticosterone + NADP+ = 11-dehydrocorticosterone + H+ + NADPHThis reaction proceeds in the forward and the backward directions.
- glycochenodeoxycholate + NADP+ = 7-oxoglycolithocholate + H+ + NADPHThis reaction proceeds in the backward direction.
- glycoursodeoxycholate + NADP+ = 7-oxoglycolithocholate + H+ + NADPHThis reaction proceeds in the backward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity | |
Molecular Function | NADP binding | |
Molecular Function | protein homodimerization activity | |
Molecular Function | steroid binding | |
Biological Process | lung development | |
Biological Process | steroid catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name11-beta-hydroxysteroid dehydrogenase 1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Physeteridae > Physeter
Accessions
- Primary accessionA0A2Y9EXA5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 7-23 | Helical | ||||
Sequence: YLLPILGIFLAYYYYSA |
Keywords
- Cellular component
Interaction
Structure
Sequence
- Sequence statusComplete
- Length294
- Mass (Da)32,223
- Last updated2018-09-12 v1
- Checksum95C6DC107ECF474D
Keywords
- Technical term