A0A2Y9EXA5 · A0A2Y9EXA5_PHYMC

Function

Catalytic activity

  • 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP+ = 3beta-hydroxy-5-androstene-7,17-dione + H+ + NADPH
    This reaction proceeds in the forward direction.
  • 3beta-hydroxy-5-androstene-7,17-dione + H+ + NADPH = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP+
    This reaction proceeds in the forward direction.
  • 3beta-hydroxy-5alpha-androstane-7,17-dione + H+ + NADPH = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP+
    This reaction proceeds in the forward direction.
  • 7-oxocholesterol + H+ + NADPH = 7beta-hydroxycholesterol + NADP+
    This reaction proceeds in the forward direction.
  • 7-oxolithocholate + H+ + NADPH = NADP+ + ursodeoxycholate
    This reaction proceeds in the forward direction.
  • 7-oxopregnenolone + H+ + NADPH = 7beta-hydroxypregnenolone + NADP+
    This reaction proceeds in the forward direction.
  • NADP+ + taurochenodeoxycholate = 7-oxotaurolithocholate + H+ + NADPH
    This reaction proceeds in the backward direction.
  • NADP+ + tauroursodeoxycholate = 7-oxotaurolithocholate + H+ + NADPH
    This reaction proceeds in the backward direction.
  • a 7beta-hydroxysteroid + NADP+ = a 7-oxosteroid + H+ + NADPH
    This reaction proceeds in the backward direction.
    EC:1.1.1.201 (UniProtKB | ENZYME | Rhea)
  • an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + H+ + NADPH
    This reaction proceeds in the forward
    and the backward
    directions.
    EC:1.1.1.146 (UniProtKB | ENZYME | Rhea)
  • chenodeoxycholate + NADP+ = 7-oxolithocholate + H+ + NADPH
    This reaction proceeds in the backward direction.
  • corticosterone + NADP+ = 11-dehydrocorticosterone + H+ + NADPH
    This reaction proceeds in the forward
    and the backward
    directions.
  • glycochenodeoxycholate + NADP+ = 7-oxoglycolithocholate + H+ + NADPH
    This reaction proceeds in the backward direction.
  • glycoursodeoxycholate + NADP+ = 7-oxoglycolithocholate + H+ + NADPH
    This reaction proceeds in the backward direction.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Function11-beta-hydroxysteroid dehydrogenase (NADP+) activity
Molecular FunctionNADP binding
Molecular Functionprotein homodimerization activity
Molecular Functionsteroid binding
Biological Processlung development
Biological Processsteroid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    11-beta-hydroxysteroid dehydrogenase 1
  • EC number
  • Alternative names
    • 7-oxosteroid reductase
    • Corticosteroid 11-beta-dehydrogenase isozyme 1

Gene names

    • Name
      HSD11B1

Organism names

Accessions

  • Primary accession
    A0A2Y9EXA5

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-23Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    294
  • Mass (Da)
    32,223
  • Last updated
    2018-09-12 v1
  • Checksum
    95C6DC107ECF474D
MAFMKKYLLPILGIFLAYYYYSAKEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAHVVVTARSEEALKKVVSHCLELGASSAHYVAGTMENMTFAEQFVAKAGKLMGGLDMLILNHITSSNNPMTVFINDIDQVRKNMEVNFLSYVVLSGAAMPMLKQSNGSIVVVSSIAGKTANPLVAAYSASKFALDGFFSSIRVEYAVTNVNVSITLCILGLIETETAMTGTAGIYNAEASPKEECALEIIKGGALRQKEVYYDSSVLTLFLLGNPGRKILEFLSLRNYNMEIFIKN

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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