A0A2X1D935 · A0A2X1D935_BREVE

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site15-20substrate
Binding site46Mg2+ (UniProtKB | ChEBI)
Active site75Proton acceptor
Binding site75Mg2+ (UniProtKB | ChEBI)
Binding site76substrate
Binding site158-161substrate
Binding site181substrate
Binding site186-187substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      NCTC11166_02762

Organism names

Accessions

  • Primary accession
    A0A2X1D935

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    200
  • Mass (Da)
    21,076
  • Last updated
    2018-09-12 v1
  • Checksum
    66E79C5A516176F7
MNLKLIKGMRIVVATHNGGKVPEISALLGGNYELVTAGQLNLPEPDETESTFTGNAMLKARHAAELSGEVSLADDSGLSVAALDGAPGIFSARWAGPGKDFAVAMKKVEERLEEIGATDRTAWFTSALAVAWPDGPCVVVQGEVHGQLTFPPRGDRGFGYDPLFIPNGGDRTFGEMEPAAKDAISHRTVAFAKLTAALID

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UAQP01000014
EMBL· GenBank· DDBJ
SPU55366.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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