A0A2X0THV3 · A0A2X0THV3_ASF

Function

function

Decapping enzyme required for the removal of the 5'-end m7GpppN cap tethered to viral and host mRNAs to allow their decay in cells. May therefore accelerate viral and cellular mRNA turnover to eliminate competing host mRNAs and allow stage-specific synthesis of viral proteins. Acceleration of the turnover of cellular transcripts may even promote the shutoff of host protein synthesis. In addition to the mRNA cap, g5R also efficiently hydrolyzes diphosphoinositol polyphosphates. Down-regulation of the level of PP-InsP5 (diphosphoinositol pentakisphosphate) may play a role in viral manipulation of the cellular secretory pathway, a step necessary for the formation of virions. Binds viral and cellular poly(A) mRNAs, thereby decreasing both types of mRNAs.

Catalytic activity

  • diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.
    EC:3.6.1.52 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

AspectTerm
Cellular Componenthost cell rough endoplasmic reticulum
Molecular Functionbis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
Molecular Functiondiphosphoinositol-polyphosphate diphosphatase activity
Molecular FunctionRNA binding
Biological ProcessAMP biosynthetic process
Biological ProcessATP biosynthetic process
Biological Processsymbiont-mediated suppression of host gene expression

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    mRNA-decapping protein g5R
  • EC number
  • Alternative names
    • ASFV-DP
    • Diphosphoinositol polyphosphate phosphohydrolase

Gene names

    • Name
      D205R CDS
    • Synonyms
      D205R
      , D250R_1
    • ORF names
      ASFV-Georgia_4-126
      , ASFV_Kyiv_2016_131_00166
      , D250R

Organism names

Accessions

  • Primary accession
    A0A2X0THV3

Proteomes

Subcellular Location

Interaction

Subunit

Interacts with host RPL23A.

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain97-243Nudix hydrolase

Sequence similarities

Belongs to the Nudix hydrolase family. DIPP subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    250
  • Mass (Da)
    29,823
  • Last updated
    2018-09-12 v1
  • Checksum
    399F922180E94F57
MDTAMQLKTSIGLITCRMNTQNNQIETILVQKRYSLAFSEFIHCHYSINANQGHLIKMFNNMTINERLLVKTLDFDRMWYHIWIETPVYELYHKKYQKFRKNWLLPDNGKKLISLINQAKGSGTLLWEIPKGKPKEDESDLTCAIREFEEETGITREYYQILPEFKKSMSYFDGKTEYKHIYFLAMLCKSLEEPNMNLSLQYENRIAEISKISWQNMEAVRFISKRQSLNLEPIIGPAFNFIKNYLRYKH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG939583
EMBL· GenBank· DDBJ
AXZ95876.1
EMBL· GenBank· DDBJ
Genomic DNA
MG939588
EMBL· GenBank· DDBJ
AXZ96159.1
EMBL· GenBank· DDBJ
Genomic DNA
MK128995
EMBL· GenBank· DDBJ
AYW34073.1
EMBL· GenBank· DDBJ
Genomic DNA
MH910495
EMBL· GenBank· DDBJ
AZP54038.1
EMBL· GenBank· DDBJ
Genomic DNA
MH910496
EMBL· GenBank· DDBJ
AZP54217.1
EMBL· GenBank· DDBJ
Genomic DNA
LR813622
EMBL· GenBank· DDBJ
CAD0059553.1
EMBL· GenBank· DDBJ
Genomic DNA
FR682468
EMBL· GenBank· DDBJ
CAD2068464.1
EMBL· GenBank· DDBJ
Genomic DNA
LR899193
EMBL· GenBank· DDBJ
CAD7112613.1
EMBL· GenBank· DDBJ
Genomic DNA
MK333180
EMBL· GenBank· DDBJ
QBH90590.1
EMBL· GenBank· DDBJ
Genomic DNA
MK333181
EMBL· GenBank· DDBJ
QBH90775.1
EMBL· GenBank· DDBJ
Genomic DNA
MK645909
EMBL· GenBank· DDBJ
QDL88133.1
EMBL· GenBank· DDBJ
Genomic DNA
MN194591
EMBL· GenBank· DDBJ
QED21702.1
EMBL· GenBank· DDBJ
Genomic DNA
MK543947
EMBL· GenBank· DDBJ
QED90545.1
EMBL· GenBank· DDBJ
Genomic DNA
MK628478
EMBL· GenBank· DDBJ
QEY87908.1
EMBL· GenBank· DDBJ
Genomic DNA
MN172368
EMBL· GenBank· DDBJ
QGJ83464.1
EMBL· GenBank· DDBJ
Genomic DNA
MN318203
EMBL· GenBank· DDBJ
QGM12744.2
EMBL· GenBank· DDBJ
Genomic DNA
MN336500
EMBL· GenBank· DDBJ
QGM12855.2
EMBL· GenBank· DDBJ
Genomic DNA
MN394630
EMBL· GenBank· DDBJ
QGM12929.2
EMBL· GenBank· DDBJ
Genomic DNA
MN715134
EMBL· GenBank· DDBJ
QGV56887.1
EMBL· GenBank· DDBJ
Genomic DNA
MK940252
EMBL· GenBank· DDBJ
QIA61516.1
EMBL· GenBank· DDBJ
Genomic DNA
MN913970
EMBL· GenBank· DDBJ
QID21283.1
EMBL· GenBank· DDBJ
Genomic DNA
MN393476
EMBL· GenBank· DDBJ
QIE06891.1
EMBL· GenBank· DDBJ
Genomic DNA
MN393477
EMBL· GenBank· DDBJ
QIE07054.1
EMBL· GenBank· DDBJ
Genomic DNA
MT496893
EMBL· GenBank· DDBJ
QLF78630.1
EMBL· GenBank· DDBJ
Genomic DNA
MT847620
EMBL· GenBank· DDBJ
QOW02572.1
EMBL· GenBank· DDBJ
Genomic DNA
MT847621
EMBL· GenBank· DDBJ
QOW02759.1
EMBL· GenBank· DDBJ
Genomic DNA
MT847622
EMBL· GenBank· DDBJ
QOW02945.1
EMBL· GenBank· DDBJ
Genomic DNA
MT847623
EMBL· GenBank· DDBJ
QOW03131.1
EMBL· GenBank· DDBJ
Genomic DNA
MT166692
EMBL· GenBank· DDBJ
QOY24207.1
EMBL· GenBank· DDBJ
Genomic DNA
MT180393
EMBL· GenBank· DDBJ
QOY24408.1
EMBL· GenBank· DDBJ
Genomic DNA
MT459800
EMBL· GenBank· DDBJ
QPB67628.1
EMBL· GenBank· DDBJ
Genomic DNA
MW465755
EMBL· GenBank· DDBJ
QSG73781.1
EMBL· GenBank· DDBJ
Genomic DNA
MN641877
EMBL· GenBank· DDBJ
QST87021.1
EMBL· GenBank· DDBJ
Genomic DNA
MN641876
EMBL· GenBank· DDBJ
QST87184.1
EMBL· GenBank· DDBJ
Genomic DNA
MW656282
EMBL· GenBank· DDBJ
QST88186.1
EMBL· GenBank· DDBJ
Genomic DNA
MW396979
EMBL· GenBank· DDBJ
QTE18832.1
EMBL· GenBank· DDBJ
Genomic DNA
MW521382
EMBL· GenBank· DDBJ
QTP96410.1
EMBL· GenBank· DDBJ
Genomic DNA
MW306190
EMBL· GenBank· DDBJ
QUQ60207.1
EMBL· GenBank· DDBJ
Genomic DNA
MW306191
EMBL· GenBank· DDBJ
QUQ60387.1
EMBL· GenBank· DDBJ
Genomic DNA
MW306192
EMBL· GenBank· DDBJ
QUQ60567.1
EMBL· GenBank· DDBJ
Genomic DNA
LS478113
EMBL· GenBank· DDBJ
SPS73525.1
EMBL· GenBank· DDBJ
Genomic DNA
LR536725
EMBL· GenBank· DDBJ
VFV48036.1
EMBL· GenBank· DDBJ
Genomic DNA
LR722599
EMBL· GenBank· DDBJ
VVW94205.1
EMBL· GenBank· DDBJ
Genomic DNA
LR722600
EMBL· GenBank· DDBJ
VVW94210.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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