A0A2X0THV3 · A0A2X0THV3_ASF
- ProteinmRNA-decapping protein g5R
- GeneD205R CDS
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids250 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Decapping enzyme required for the removal of the 5'-end m7GpppN cap tethered to viral and host mRNAs to allow their decay in cells. May therefore accelerate viral and cellular mRNA turnover to eliminate competing host mRNAs and allow stage-specific synthesis of viral proteins. Acceleration of the turnover of cellular transcripts may even promote the shutoff of host protein synthesis. In addition to the mRNA cap, g5R also efficiently hydrolyzes diphosphoinositol polyphosphates. Down-regulation of the level of PP-InsP5 (diphosphoinositol pentakisphosphate) may play a role in viral manipulation of the cellular secretory pathway, a step necessary for the formation of virions. Binds viral and cellular poly(A) mRNAs, thereby decreasing both types of mRNAs.
Catalytic activity
Cofactor
Protein has several cofactor binding sites:
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell rough endoplasmic reticulum | |
Molecular Function | bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity | |
Molecular Function | diphosphoinositol-polyphosphate diphosphatase activity | |
Molecular Function | RNA binding | |
Biological Process | AMP biosynthetic process | |
Biological Process | ATP biosynthetic process | |
Biological Process | symbiont-mediated suppression of host gene expression |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namemRNA-decapping protein g5R
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageViruses > Varidnaviria > Bamfordvirae > Nucleocytoviricota > Pokkesviricetes > Asfuvirales > Asfarviridae > Asfivirus
- Virus hosts
Accessions
- Primary accessionA0A2X0THV3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Interacts with host RPL23A.
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 97-243 | Nudix hydrolase | ||||
Sequence: QKFRKNWLLPDNGKKLISLINQAKGSGTLLWEIPKGKPKEDESDLTCAIREFEEETGITREYYQILPEFKKSMSYFDGKTEYKHIYFLAMLCKSLEEPNMNLSLQYENRIAEISKISWQNMEAVRFISKRQSLNLEPIIGPAFNFIK |
Sequence similarities
Belongs to the Nudix hydrolase family. DIPP subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length250
- Mass (Da)29,823
- Last updated2018-09-12 v1
- Checksum399F922180E94F57
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MG939583 EMBL· GenBank· DDBJ | AXZ95876.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG939588 EMBL· GenBank· DDBJ | AXZ96159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK128995 EMBL· GenBank· DDBJ | AYW34073.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH910495 EMBL· GenBank· DDBJ | AZP54038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH910496 EMBL· GenBank· DDBJ | AZP54217.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR813622 EMBL· GenBank· DDBJ | CAD0059553.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FR682468 EMBL· GenBank· DDBJ | CAD2068464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR899193 EMBL· GenBank· DDBJ | CAD7112613.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK333180 EMBL· GenBank· DDBJ | QBH90590.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK333181 EMBL· GenBank· DDBJ | QBH90775.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK645909 EMBL· GenBank· DDBJ | QDL88133.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN194591 EMBL· GenBank· DDBJ | QED21702.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK543947 EMBL· GenBank· DDBJ | QED90545.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK628478 EMBL· GenBank· DDBJ | QEY87908.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN172368 EMBL· GenBank· DDBJ | QGJ83464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN318203 EMBL· GenBank· DDBJ | QGM12744.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN336500 EMBL· GenBank· DDBJ | QGM12855.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN394630 EMBL· GenBank· DDBJ | QGM12929.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN715134 EMBL· GenBank· DDBJ | QGV56887.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK940252 EMBL· GenBank· DDBJ | QIA61516.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN913970 EMBL· GenBank· DDBJ | QID21283.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN393476 EMBL· GenBank· DDBJ | QIE06891.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN393477 EMBL· GenBank· DDBJ | QIE07054.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT496893 EMBL· GenBank· DDBJ | QLF78630.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT847620 EMBL· GenBank· DDBJ | QOW02572.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT847621 EMBL· GenBank· DDBJ | QOW02759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT847622 EMBL· GenBank· DDBJ | QOW02945.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT847623 EMBL· GenBank· DDBJ | QOW03131.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT166692 EMBL· GenBank· DDBJ | QOY24207.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT180393 EMBL· GenBank· DDBJ | QOY24408.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT459800 EMBL· GenBank· DDBJ | QPB67628.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW465755 EMBL· GenBank· DDBJ | QSG73781.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN641877 EMBL· GenBank· DDBJ | QST87021.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN641876 EMBL· GenBank· DDBJ | QST87184.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW656282 EMBL· GenBank· DDBJ | QST88186.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW396979 EMBL· GenBank· DDBJ | QTE18832.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW521382 EMBL· GenBank· DDBJ | QTP96410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW306190 EMBL· GenBank· DDBJ | QUQ60207.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW306191 EMBL· GenBank· DDBJ | QUQ60387.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW306192 EMBL· GenBank· DDBJ | QUQ60567.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LS478113 EMBL· GenBank· DDBJ | SPS73525.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR536725 EMBL· GenBank· DDBJ | VFV48036.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR722599 EMBL· GenBank· DDBJ | VVW94205.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR722600 EMBL· GenBank· DDBJ | VVW94210.1 EMBL· GenBank· DDBJ | Genomic DNA |