A0A2X0SFD0 · A0A2X0SFD0_HUMAN
- ProteinARHGAP32
- GeneARHGAP32
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2089 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | actin cytoskeleton | |
Cellular Component | cell cortex | |
Cellular Component | fibrillar center | |
Cellular Component | Golgi apparatus | |
Cellular Component | nucleoplasm | |
Molecular Function | GTPase activator activity | |
Molecular Function | phosphatidylinositol phosphate binding | |
Biological Process | small GTPase-mediated signal transduction |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineagecellular organisms > Eukaryota (eucaryotes) > Opisthokonta > Metazoa (metazoans) > Eumetazoa > Bilateria > Deuterostomia > Chordata (chordates) > Craniata > Vertebrata (vertebrates) > Gnathostomata (jawed vertebrates) > Teleostomi > Euteleostomi (bony vertebrates) > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda (tetrapods) > Amniota (amniotes) > Mammalia (mammals) > Theria > Eutheria (placentals) > Boreoeutheria > Euarchontoglires > Primates > Haplorrhini > Simiiformes > Catarrhini > Hominoidea (apes) > Hominidae (great apes) > Homininae > Homo
Accessions
- Primary accessionA0A2X0SFD0
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 259-321 | SH3 | ||||
Sequence: PAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQVGLFPGHCVELINQ | ||||||
Domain | 372-567 | Rho-GAP | ||||
Sequence: CDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLF | ||||||
Region | 818-858 | Disordered | ||||
Sequence: FLDSPGYSKDKPSANKKDAETGSSQCQTPGSTASSEPVSPL | ||||||
Compositional bias | 835-858 | Polar residues | ||||
Sequence: DAETGSSQCQTPGSTASSEPVSPL | ||||||
Region | 927-1038 | Disordered | ||||
Sequence: SNTTAQNASSSTWDKCVEERDATNRSPTQIVKMKTNETVAQEAYESEVQPLDQVAAEEVELPGKEDQSVSSSQSKAVASGQTQTGAVTHDPPQDSVPVSSVSLIPPPPPPKN | ||||||
Compositional bias | 949-969 | Polar residues | ||||
Sequence: TNRSPTQIVKMKTNETVAQEA | ||||||
Compositional bias | 991-1026 | Polar residues | ||||
Sequence: EDQSVSSSQSKAVASGQTQTGAVTHDPPQDSVPVSS | ||||||
Region | 1103-1143 | Disordered | ||||
Sequence: PAEQFHLQNNAPGNCDHPLPETTATGDPTHSNTTESGEQHH | ||||||
Compositional bias | 1126-1143 | Polar residues | ||||
Sequence: ATGDPTHSNTTESGEQHH | ||||||
Compositional bias | 1169-1184 | Basic and acidic residues | ||||
Sequence: VPLDSEKSDDHVSFPE | ||||||
Region | 1169-1257 | Disordered | ||||
Sequence: VPLDSEKSDDHVSFPEDQSGKNSMPTVSFLDQDQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDKIYPPSGSPEENTS | ||||||
Compositional bias | 1185-1209 | Polar residues | ||||
Sequence: DQSGKNSMPTVSFLDQDQSPPRFYS | ||||||
Region | 1798-1896 | Disordered | ||||
Sequence: PGKTGLLSVAEGKESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGSTQPEKPSLPQKQSSLRSRKLPDMGCSLPEHRAHQEASHRQFCESKNGPP | ||||||
Compositional bias | 1810-1847 | Basic and acidic residues | ||||
Sequence: KESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGS | ||||||
Compositional bias | 1850-1866 | Polar residues | ||||
Sequence: PEKPSLPQKQSSLRSRK | ||||||
Compositional bias | 1870-1887 | Basic and acidic residues | ||||
Sequence: MGCSLPEHRAHQEASHRQ |
Sequence similarities
Belongs to the PX domain-containing GAP family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length2,089
- Mass (Da)230,755
- Last updated2018-09-12 v1
- Checksum2BA2E75E5B490285
Features
Showing features for compositional bias, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 835-858 | Polar residues | ||||
Sequence: DAETGSSQCQTPGSTASSEPVSPL | ||||||
Compositional bias | 949-969 | Polar residues | ||||
Sequence: TNRSPTQIVKMKTNETVAQEA | ||||||
Compositional bias | 991-1026 | Polar residues | ||||
Sequence: EDQSVSSSQSKAVASGQTQTGAVTHDPPQDSVPVSS | ||||||
Compositional bias | 1126-1143 | Polar residues | ||||
Sequence: ATGDPTHSNTTESGEQHH | ||||||
Compositional bias | 1169-1184 | Basic and acidic residues | ||||
Sequence: VPLDSEKSDDHVSFPE | ||||||
Compositional bias | 1185-1209 | Polar residues | ||||
Sequence: DQSGKNSMPTVSFLDQDQSPPRFYS | ||||||
Compositional bias | 1810-1847 | Basic and acidic residues | ||||
Sequence: KESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGS | ||||||
Compositional bias | 1850-1866 | Polar residues | ||||
Sequence: PEKPSLPQKQSSLRSRK | ||||||
Compositional bias | 1870-1887 | Basic and acidic residues | ||||
Sequence: MGCSLPEHRAHQEASHRQ | ||||||
Non-terminal residue | 2089 | |||||
Sequence: I |