A0A2W1BER1 · A0A2W1BER1_HELAM
- Proteinm7GpppX diphosphatase
- GeneHaOG210564
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids340 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
Catalytic activity
- a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H+ + N7-methyl-GMP
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 163 | substrate | ||||
Sequence: W | ||||||
Binding site | 173 | substrate | ||||
Sequence: E | ||||||
Binding site | 193 | substrate | ||||
Sequence: D | ||||||
Binding site | 195 | substrate | ||||
Sequence: K | ||||||
Binding site | 256-267 | substrate | ||||
Sequence: HYQPSFYHLHVH | ||||||
Active site | 265 | Nucleophile | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | P-body | |
Molecular Function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity | |
Molecular Function | RNA 7-methylguanosine cap binding | |
Biological Process | deadenylation-dependent decapping of nuclear-transcribed mRNA | |
Biological Process | mRNA processing |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namem7GpppX diphosphatase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Noctuoidea > Noctuidae > Heliothinae > Helicoverpa
Accessions
- Primary accessionA0A2W1BER1
Proteomes
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length340
- Mass (Da)39,887
- Last updated2018-09-12 v1
- Checksum027F98116EC478B1
Keywords
- Technical term