A0A2W1B4U0 · A0A2W1B4U0_HELAM

Function

function

Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionFAD-AMP lyase (cyclizing) activity
Molecular Functionglycerone kinase activity
Biological Processglycerol catabolic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Triokinase/FMN cyclase
  • EC number
  • Alternative names
    • Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)

Gene names

    • Name
      HaOG213660
    • ORF names
      B5X24_HaOG213660

Organism names

Accessions

  • Primary accession
    A0A2W1B4U0

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer. Interacts with IFIH1 (via the CARD domains), the interaction is inhibited by viral infection.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-338DhaK
Domain377-575DhaL

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    581
  • Mass (Da)
    61,121
  • Last updated
    2018-09-12 v1
  • Checksum
    65EB307BBC386926
MSSNKPVTKKIINSPQTCVDDNLRGVVATYPSLQLHPKHRVITVRQKSDTGRVAILGGGGSGHEPFAAGFVGAGLLDGAVAGGVFASPPTGHVLYAIAHLYKYNSGGVLVIIGNYTGDRLNFGKAIEKAKISGIKVEGLIVGEDVASCKNKTGGRSMVGEVLFYKLAGALAAKGYDLATIRKEAAEFNKYMATLGVCLSTCSLPGQPPLFEIAHDEMELGAGVHGEAGITKMKMGTAKEVVAMILEQIISHLKLVAGNRVVVTIDNLGGTSIFEMNIISAEVKDHLESKKIKVERIFSGHFKTSLEMQGFQICVLHLNEEKGDLWLETLDAPTGGSAWTGGVLSVRSEGGHVDDDTLLQSHGAKAKSGPALNPKEQELLRGSLLSAAEQLVKSEALLNKLDSGCGDGDCGITIKNFGIAIQSYLKTASVEYPSNVLWDLSEIAETDMGGTSGGIYSLGLSAASQAMASAKSNDVASWLAAWESAIQAISKYGGAEPGDRTMLDTLHHAAEAFKQNLSADLKALLKKTAEASEQGAKATVKMVARAGRASYVASGYMNDEDAGARAAAVWLQAILNYVTNNI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KZ150341
EMBL· GenBank· DDBJ
PZC71309.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp