A0A2W1ALA2 · A0A2W1ALA2_UNCCH

  • Protein
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • Gene
    nnrD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site257(6S)-NADPHX (UniProtKB | ChEBI)
Binding site329(6S)-NADPHX (UniProtKB | ChEBI)
Binding site382(6S)-NADPHX (UniProtKB | ChEBI)
Binding site419-423AMP (UniProtKB | ChEBI)
Binding site448AMP (UniProtKB | ChEBI)
Binding site449(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionADP-dependent NAD(P)H-hydrate dehydratase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Biological Processmetabolite repair
Biological Processnicotinamide nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ADP-dependent NAD(P)HX dehydratase

Gene names

    • Name
      nnrD
    • ORF names
      DK303_000992

Organism names

Accessions

  • Primary accession
    A0A2W1ALA2

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-214YjeF N-terminal
Domain222-508YjeF C-terminal

Sequence similarities

Belongs to the NnrD/CARKD family.
In the C-terminal section; belongs to the NnrD/CARKD family.
In the N-terminal section; belongs to the NnrE/AIBP family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    510
  • Mass (Da)
    54,517
  • Last updated
    2018-09-12 v1
  • Checksum
    352F9FAB8FDAC527
MRDLEARSETLGISTNELMNNAGFSIASHIAKNMGPLKGLKVVSLVGTGNNGSDCLIASGHLAKWGASVTAVILKPRSEPDLRRQETLRMGISLIDISEVKENYSFFSVHSLLRNAHIIVDGILGIGTSLPIRDPFKTVLSDIRALNEKKAKVFSIDVPSGVDSDTSAVDSSAFKPDVTLALGHLKPCHVNQPAADFCGEIIICDIGLPNHLSVEINTALLCDEYVRLILPGRSTSSHKGSYGKAMVVGGSDNYIGAPVLAASSAMKTGLGLVTIATFEHLVNPMANMFPEATFLSLKEDGMDIRSGQYMARQIFEAVEDYKVLLIGCGFGTSRTTYRIFRNLVLSDIKLPQLVLDADGLNMLSKISNWWGKIPFNTILTPHPKEMSRLTRLPVSEIQSDRLNVAKTFSKQWGVIVVLKGANTVICDPNGSSTISPFANPILSSAGTGDVLAGLIAGFVGQGSSPLEASSLGVYTHGKTAESISLQIGSSGLLATELANNVPFTIKHLRD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QGNN01000019
EMBL· GenBank· DDBJ
PZC42514.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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