A0A2V6U121 · A0A2V6U121_9BACT

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site117(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site121-123(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site225Plays an important role in substrate specificity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functioncobalt ion binding
Molecular FunctionDNA binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionmethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processmethylation
Biological Processnegative regulation of DNA-templated transcription
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase
  • Recommended name
    Transcriptional repressor NrdR

Gene names

    • Name
      glyA
    • Synonyms
      nrdR
    • ORF names
      DME10_06655

Organism names

Accessions

  • Primary accession
    A0A2V6U121

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue226N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain442-532ATP-cone

Sequence similarities

Belongs to the NrdR family.
Belongs to the SHMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    559
  • Mass (Da)
    61,205
  • Last updated
    2018-09-12 v1
  • Checksum
    9BC9CCE353FA8502
MSGLEHVDPEIARAIRDETVRQSRNLELIASENFVSEAVLEATGSVMTNKYAEGYPGKRYYGGCEIVDVAENLAISRAKALFGAEHVNVQPHSGSQANMAVYFTLLKPGDVVLGPNLAHGGHLTAGSPMNFSGRLYTIVPYGVTRDTEQIDLDQVRDLAKQHRPKLIIAGGSAFPRAIDFKPFREIADEAGAALMADIAHPAGLVAAGLHPSPVPYADFVTTTTHKTLRGPRGGMVMCRSAYAKDLDRTVLPGIQGGPLMHVIAAKAVAFREAQTPEWRVYQAQIIKNAKALAEALLALGYRLVSGGTDTHLLLVDLTPKGITGKDAQEALDRAWITVNKNGIPFDTKGPMVTSGVRLGTPAVTTRGMREPEMAQIAALIDGVLGSLGNATAEAKVRGEVEELTSRVDSRVGREGEFIRRRRECLKCHRRYTTYEYIEDVLPHVVKRDGRREPFDRQKLRGSILKSCEKRSVGVQAVDDVVADIEARLHERAEKEITSLEMGEIVMEHLQKLDQVAYVRFASVYRQFKDISQFMDEVKGLIKDGDKSKAPKPAKPAPKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QHSF01000129
EMBL· GenBank· DDBJ
PYM74333.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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