A0A2V5JTX9 · A0A2V5JTX9_UNCVE

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site86substrate
Binding site216-218substrate
Binding site225Mn2+ (UniProtKB | ChEBI)
Binding site245Mn2+ (UniProtKB | ChEBI)
Binding site267substrate
Binding site268-273GTP (UniProtKB | ChEBI)
Active site269
Binding site294Mn2+ (UniProtKB | ChEBI)
Binding site383-385substrate
Binding site385GTP (UniProtKB | ChEBI)
Binding site416GTP (UniProtKB | ChEBI)
Binding site509-512GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      DMF10_00210
      , DMF11_12230

Organism names

Accessions

  • Primary accession
    A0A2V5JTX9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain26-237Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain241-597Phosphoenolpyruvate carboxykinase C-terminal P-loop
Region378-399Disordered

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    601
  • Mass (Da)
    66,970
  • Last updated
    2018-09-12 v1
  • Checksum
    9573AE2E9D9E17DC
MKNPAPAIFPPSGIGDARPANQAVLDWVHEIATLTEPENIFWCDGSDRENEFLVAESLKQNVLIKPNQKKVPQSYLHRSDPNDVARVEQFTFVCTPTKEEAGPTNNWSDPEQTYAKLRGLLKGAMRERTMFVIPYMMGPADSSLTKIGFEITDSKYVVLNMRIMTRMGEIAVKRLGNDPNAEWNRGVHSLLDVNPERRFICHFPQDNTIISVGSGYGGNVLLSKKCLALRIGSYLARTQGWMAEHMLILGVESPEGRKHYVAAAFPSACGKTNFAMLIPPAHFKGWKVTTIGDDIGWMQIRDGRLYAVNPENGYFGVLPGTSNSSNPNAMKSIAHDTIYTNAALSDDGDVWWEGKDGPRPAHAIDWRGKDWTSASKERAAHPNSRFTTPIRNNPALDPDVEKGEGVPISAIIFGGRRSDTVPLVYQAFDWAHGVYLGATMASETTAAAAGAVGRVRRDPMAMLPFCGYNIGDYFQHWLDIGNRLTNPPLIFNVNWFRKGVKGQFLWPGFGENMRVLKWIIDRCEETGGALKSPIGWLPSPHDLDLAELDIDHKCVAEILGIDHEEWAKELAEHKKFFDSLGGVVPKQLLEQREQLAARFKE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QHMS01000269
EMBL· GenBank· DDBJ
PYI45387.1
EMBL· GenBank· DDBJ
Genomic DNA
QHMT01000006
EMBL· GenBank· DDBJ
PYI49898.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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