A0A2V5JTX9 · A0A2V5JTX9_UNCVE
- ProteinPhosphoenolpyruvate carboxykinase [GTP]
- GenepckG
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids601 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Catalytic activity
- oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
Cofactor
Note: Binds 1 Mn2+ ion per subunit.
Pathway
Carbohydrate biosynthesis; gluconeogenesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 86 | substrate | |||
Binding site | 216-218 | substrate | |||
Binding site | 225 | Mn2+ (UniProtKB | ChEBI) | |||
Binding site | 245 | Mn2+ (UniProtKB | ChEBI) | |||
Binding site | 267 | substrate | |||
Binding site | 268-273 | GTP (UniProtKB | ChEBI) | |||
Active site | 269 | ||||
Binding site | 294 | Mn2+ (UniProtKB | ChEBI) | |||
Binding site | 383-385 | substrate | |||
Binding site | 385 | GTP (UniProtKB | ChEBI) | |||
Binding site | 416 | GTP (UniProtKB | ChEBI) | |||
Binding site | 509-512 | GTP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | GTP binding | |
Molecular Function | kinase activity | |
Molecular Function | manganese ion binding | |
Molecular Function | phosphoenolpyruvate carboxykinase (GTP) activity | |
Biological Process | cellular response to glucose stimulus | |
Biological Process | gluconeogenesis | |
Biological Process | glycerol biosynthetic process from pyruvate | |
Biological Process | phosphorylation | |
Biological Process | propionate catabolic process | |
Biological Process | response to lipid | |
Biological Process | response to starvation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoenolpyruvate carboxykinase [GTP]
- EC number
- Short namesPEP carboxykinase ; PEPCK
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Verrucomicrobiota
Accessions
- Primary accessionA0A2V5JTX9
Proteomes
Subcellular Location
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 26-237 | Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal | |||
Domain | 241-597 | Phosphoenolpyruvate carboxykinase C-terminal P-loop | |||
Region | 378-399 | Disordered | |||
Sequence similarities
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length601
- Mass (Da)66,970
- Last updated2018-09-12 v1
- Checksum9573AE2E9D9E17DC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
QHMS01000269 EMBL· GenBank· DDBJ | PYI45387.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QHMT01000006 EMBL· GenBank· DDBJ | PYI49898.1 EMBL· GenBank· DDBJ | Genomic DNA |