A0A2V4U8D4 · A0A2V4U8D4_9GAMM
- ProteinNa(+)-translocating NADH-quinone reductase subunit F
- GenenqrF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids411 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
Catalytic activity
- a ubiquinone + n Na+(in) + NADH + H+ = a ubiquinol + n Na+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + n Na+ (in)CHEBI:29101+ CHEBI:57945 + CHEBI:15378 = a ubiquinol RHEA-COMP:9566 + n Na+ (out)CHEBI:29101+ CHEBI:57540
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 [2Fe-2S] cluster.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | electron transfer activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | |
Biological Process | sodium ion transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNa(+)-translocating NADH-quinone reductase subunit F
- EC number
- Short namesNa(+)-NQR subunit F ; Na(+)-translocating NQR subunit F
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Psychrobacter
Accessions
- Primary accessionA0A2V4U8D4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-27 | Helical | ||||
Sequence: AIGGVAMFTLIIMGLVAIILAA |
Keywords
- Cellular component
Interaction
Subunit
Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 35-129 | 2Fe-2S ferredoxin-type | ||||
Sequence: GDVTIHINDNSDNDVVTPAGGKLLQTLASEGIFLSSACGGGGTCAQCRCRVIEGGGSILPTEEGYFTQGEIRNHMRLACQVAVKQDMKIEIDPEF | ||||||
Domain | 132-273 | FAD-binding FR-type | ||||
Sequence: VQKWECEVVSNDNVATFIKELVLKIPEGEEVNFRAGGYVQLEAPPHEVHYKDFDVAEEYREDWDKFGIFNYVSKVDEPVIRAYSMANYPEEKGLIKFNIRIASPPPRGPDGIPPGKMSSWTFSLKPGDKVTVSGPYGEFFAK |
Sequence similarities
Belongs to the NqrF family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length411
- Mass (Da)45,853
- Last updated2018-09-12 v1
- Checksum6E11C94D234E9B1F