A0A2V3IEH1 · A0A2V3IEH1_9FLOR

  • Protein
    Fanconi-associated nuclease
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
    EC:3.1.4.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Function5'-3' exonuclease activity
Molecular Function5'-flap endonuclease activity
Molecular Functionflap-structured DNA binding
Molecular Functionmetal ion binding
Molecular Functionphosphodiesterase I activity
Biological Processinterstrand cross-link repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fanconi-associated nuclease
  • EC number

Gene names

    • ORF names
      BWQ96_09808

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SKKU-2015
  • Taxonomic lineage
    Eukaryota > Rhodophyta > Florideophyceae > Rhodymeniophycidae > Gracilariales > Gracilariaceae > Gracilariopsis

Accessions

  • Primary accession
    A0A2V3IEH1

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-37Disordered
Compositional bias94-122Polar residues
Region94-136Disordered
Region741-769Disordered
Compositional bias745-764Basic and acidic residues
Domain946-1053VRR-NUC

Sequence similarities

Belongs to the FAN1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,084
  • Mass (Da)
    122,169
  • Last updated
    2018-09-12 v1
  • Checksum
    6F744501F80262CE
MEDDCFPVSSQLGFSDEGKDDHVASPSKRPKKRPCTACFSLENNRPALPEHQDSPTLSKASFYTRGLESNNALPPPVFLPITNHSNVSLAEAVPSDGSLSLPSRATHARQRSPPSTSRRASVEPISRDGAVLNPSQGQRIATLPKSSVLDPTMGMCAPFADHNNVCRKGDTMFLGAQEIPEIPSPPVFSSDEDDQIKNEEKLITTSANQLRKTRMEHAHQKDTRNAKKGNSSHVIMAKHENRNQTQLIVDTGNPPEDSKNSSYFSFSRVLVEQELKTESKEKNLDEQTEHPIKPNKRYYMRAFDYVVTQVLSRYRLVLSEHDVKTVNLIKLGITHNAQALFIRVYRRKQPQWYRTSGLEESYRTEFDVSAAIEELCEKNIMISSKYAAEGSETGALVLARDLISTCSLDEVRQLCGSLIDGKKLRKLPKSKLLPTLKNILLESFSKKTRKRKLRQTTLTGATPSQNLARAVLRTAGHSIRIPEHILTSLEKVHFLFFLEDGHDSPNVILADTGKAKFPSYICDSRAMIFPSRTAYENYRTALALEQELDSVLATKSYNEAADLGSIAELEVREFFKTPTEGDGIICDMKYSDRVSEIKEQWTSLICRNASARSAVQKEEHKRQIEAQLEHPFFRRFTAQWVYVRACWHAVHALECLREYESAVRLLQLILSTSLVPKRRGKCLNRLTINMFKHLGRLREALGVVRDALDSKEFRLHLGDRQALARRGVAIHKKITAQSQKAVRSAKQLRSEESALDRDPEESGSTPELPDVVTQALKETEEEIVVRKILGKSLNVQAREQQTRKAVMRDKSVDMWRQDVREESIDSVTPVVKSTFSVNGKAWFSSLTSNGATVSVEEYCMEWYTAKEGWVGKHDEGKSIRFLFCLIMWETAMFASVPDVFQTPYQDRPLDLFTEAFFKSRAEAIENRLHEVFSWLPSRVFSEITSQYEEYMGTRAIACDWNSYSVSDLATIGAGLGGPVLSHCFRLLSLDYSYWGGGLPDLTLWKRDDNCQSICHTKLVEVKSARDTLSEVQRAWLLELRKAGASCEVCKVVEKVTSVNAHELELAALGFQSIGALSASRADKE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias94-122Polar residues
Compositional bias745-764Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NBIV01000290
EMBL· GenBank· DDBJ
PXF40485.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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