A0A2V3IEH1 · A0A2V3IEH1_9FLOR
- ProteinFanconi-associated nuclease
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1084 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Catalytic activity
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | 5'-3' exonuclease activity | |
Molecular Function | 5'-flap endonuclease activity | |
Molecular Function | flap-structured DNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | phosphodiesterase I activity | |
Biological Process | interstrand cross-link repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFanconi-associated nuclease
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Rhodophyta > Florideophyceae > Rhodymeniophycidae > Gracilariales > Gracilariaceae > Gracilariopsis
Accessions
- Primary accessionA0A2V3IEH1
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-37 | Disordered | ||||
Sequence: MEDDCFPVSSQLGFSDEGKDDHVASPSKRPKKRPCTA | ||||||
Compositional bias | 94-122 | Polar residues | ||||
Sequence: PSDGSLSLPSRATHARQRSPPSTSRRASV | ||||||
Region | 94-136 | Disordered | ||||
Sequence: PSDGSLSLPSRATHARQRSPPSTSRRASVEPISRDGAVLNPSQ | ||||||
Region | 741-769 | Disordered | ||||
Sequence: AVRSAKQLRSEESALDRDPEESGSTPELP | ||||||
Compositional bias | 745-764 | Basic and acidic residues | ||||
Sequence: AKQLRSEESALDRDPEESGS | ||||||
Domain | 946-1053 | VRR-NUC | ||||
Sequence: QYEEYMGTRAIACDWNSYSVSDLATIGAGLGGPVLSHCFRLLSLDYSYWGGGLPDLTLWKRDDNCQSICHTKLVEVKSARDTLSEVQRAWLLELRKAGASCEVCKVVE |
Sequence similarities
Belongs to the FAN1 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,084
- Mass (Da)122,169
- Last updated2018-09-12 v1
- Checksum6F744501F80262CE
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 94-122 | Polar residues | ||||
Sequence: PSDGSLSLPSRATHARQRSPPSTSRRASV | ||||||
Compositional bias | 745-764 | Basic and acidic residues | ||||
Sequence: AKQLRSEESALDRDPEESGS |
Keywords
- Technical term