A0A2V0MS25 · A0A2V0MS25_9MYCO

Function

function

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site226L-serine (UniProtKB | ChEBI)
Binding site226-228L-serine (UniProtKB | ChEBI)
Binding site257L-serine (UniProtKB | ChEBI)
Binding site257-259ATP (UniProtKB | ChEBI)
Binding site273ATP (UniProtKB | ChEBI)
Binding site273-276ATP (UniProtKB | ChEBI)
Binding site280L-serine (UniProtKB | ChEBI)
Binding site344-347ATP (UniProtKB | ChEBI)
Binding site377L-serine (UniProtKB | ChEBI)
Binding site379L-serine (UniProtKB | ChEBI)
Site379Important for serine binding

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionserine-tRNA ligase activity
Molecular FunctiontRNA binding
Biological Processselenocysteine biosynthetic process
Biological Processseryl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine--tRNA ligase
  • EC number
  • Alternative names
    • Seryl-tRNA synthetase
      (SerRS
      )
    • Seryl-tRNA(Ser/Sec) synthetase

Gene names

    • Name
      serS
    • ORF names
      MFM001_05580

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MFM001
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium

Accessions

  • Primary accession
    A0A2V0MS25

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer. The tRNA molecule binds across the dimer.

Family & Domains

Features

Showing features for compositional bias, region, coiled coil, domain.

Type
IDPosition(s)Description
Compositional bias1-23Basic and acidic residues
Region1-25Disordered
Coiled coil67-94
Domain135-403Aminoacyl-transfer RNA synthetases class-II family profile

Domain

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    419
  • Mass (Da)
    45,318
  • Last updated
    2018-09-12 v1
  • Checksum
    CCE76212B734AB3B
MIDLKLLREDPDAVRRSQRSRGEDPALVDTLLAADAARRAAISAADSLRAEQKAASKKVGAASPDERPALLAEAKELAERVKAAEAEQADAEAAFTAAHMAISNVIIDGVPAGGEDDYAVLDVVGEPTAIENPRDHLELGESLGLIDMERGAKVSGSRFYFLTGRGALLQLGLLQLAVRLAVDNGFVPMIPPVLVRPDVMSGTGFLGAHAEEVYHLDADDLYLVGTSEVPLAGYHSDEILDLSGGPLRYAGWSSCFRREAGSHGKDTRGIIRVHQFDKVEGFVYCMPADAEAEHQRLLGWQREMLARIEVPYRVIDVAAGDLGSSAARKFDCEAWIPTQGAYRELTSTSNCTTFQARRLATRYRDENGKPQIAATLNGTLATTRWLVAILENHQRPDGTVRVPEALVPFVGTELLEPLG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-23Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BFAB01000001
EMBL· GenBank· DDBJ
GBE64096.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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