A0A2U9AGA3 · A0A2U9AGA3_ADET1

Function

function

Hexon-linking protein-C: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.
Hexon-linking protein-N: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for site.

122720406080100120140160180200220
TypeIDPosition(s)Description
Site111-112Cleavage; by viral protease
Site156-157Cleavage; by viral protease

GO annotations

AspectTerm
Cellular Componenthost cell nucleus
Cellular Componentviral capsid
Molecular Functionhexon binding

Names & Taxonomy

Protein names

  • Recommended name
    Pre-hexon-linking protein VIII
  • Alternative names
    • Pre-protein VIII
      (pVIII
      )
  • Cleaved into 2 chains
    • Hexon-linking protein-N
      Alternative names: 12.1 kDa protein VIII
      , Protein VIII-N
    • Hexon-linking protein-C
      Alternative names: 7.6 kDa protein VIII
      , Protein VIII-C

Gene names

    • Name
      L4

Organism names

Accessions

  • Primary accession
    A0A2U9AGA3

Proteomes

Subcellular Location

Hexon-linking protein-N

Virion
Note: Located on the inner side of the capsid shell. Present in 120 copies per virion.

Hexon-linking protein-C

Virion
Note: Located on the inner side of the capsid shell. Present in 120 copies per virion.

Pre-hexon-linking protein VIII

Host nucleus

Keywords

PTM/Processing

Features

Showing features for peptide, chain, modified residue.

TypeIDPosition(s)Description
PeptidePRO_50161837711-111Hexon-linking protein-N
ChainPRO_50232240951-227Pre-hexon-linking protein VIII
Modified residue64Phosphothreonine; by host
PeptidePRO_5016183772157-227Hexon-linking protein-C

Post-translational modification

Cleaved by the viral protease during virion maturation. May cause the middle segment to be shed from the capsid.

Keywords

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Interacts with the peripentonal hexons as well as the hexons in the facets. Part of a complex composed of the core-capsid bridging protein, the endosome lysis protein VI and the hexon-linking protein VIII; these interactions bridge the virus core to the capsid.

Family & Domains

Sequence similarities

Belongs to the adenoviridae hexon-linking protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    227
  • Mass (Da)
    24,847
  • Last updated
    2018-09-12 v1
  • Checksum
    B35E9B1F1A925F83
MSKDIPTPYVWTFQPQMGAAAGASQDYGTKMNWLSAGPSMIHRVNNIREARNRILLRQAALTETPRTVMNPPNWPSALLYHDVAPPTSVPLPRNERLEIAMTNHGAQLAGGGHTSLPEGLKRELLFGSGIQLNEQLPVRPYGAAVRADGTFQLAGGSRSSFNPREELFLKLQSAPSQPRSGGIGSWQFVEEFVPAVYYNPFSGPPGTYPDQFISNYDVVSDSVDGYD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MF780605
EMBL· GenBank· DDBJ
AWO77115.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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