A0A2U9AGA3 · A0A2U9AGA3_ADET1
- ProteinPre-hexon-linking protein VIII
- GeneL4
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids227 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Hexon-linking protein-C: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.
Hexon-linking protein-N: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.
Miscellaneous
All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 111-112 | Cleavage; by viral protease | ||||
Sequence: GG | ||||||
Site | 156-157 | Cleavage; by viral protease | ||||
Sequence: GS |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell nucleus | |
Cellular Component | viral capsid | |
Molecular Function | hexon binding |
Names & Taxonomy
Protein names
- Recommended namePre-hexon-linking protein VIII
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Varidnaviria > Bamfordvirae > Preplasmiviricota > Tectiliviricetes > Rowavirales > Adenoviridae > Mastadenovirus > Tree shrew mastadenovirus A
- Virus hosts
Accessions
- Primary accessionA0A2U9AGA3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Hexon-linking protein-N
Note: Located on the inner side of the capsid shell. Present in 120 copies per virion.
Hexon-linking protein-C
Note: Located on the inner side of the capsid shell. Present in 120 copies per virion.
Pre-hexon-linking protein VIII
Keywords
- Cellular component
PTM/Processing
Features
Showing features for peptide, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Peptide | PRO_5016183771 | 1-111 | Hexon-linking protein-N | |||
Sequence: MSKDIPTPYVWTFQPQMGAAAGASQDYGTKMNWLSAGPSMIHRVNNIREARNRILLRQAALTETPRTVMNPPNWPSALLYHDVAPPTSVPLPRNERLEIAMTNHGAQLAGG | ||||||
Chain | PRO_5023224095 | 1-227 | Pre-hexon-linking protein VIII | |||
Sequence: MSKDIPTPYVWTFQPQMGAAAGASQDYGTKMNWLSAGPSMIHRVNNIREARNRILLRQAALTETPRTVMNPPNWPSALLYHDVAPPTSVPLPRNERLEIAMTNHGAQLAGGGHTSLPEGLKRELLFGSGIQLNEQLPVRPYGAAVRADGTFQLAGGSRSSFNPREELFLKLQSAPSQPRSGGIGSWQFVEEFVPAVYYNPFSGPPGTYPDQFISNYDVVSDSVDGYD | ||||||
Modified residue | 64 | Phosphothreonine; by host | ||||
Sequence: T | ||||||
Peptide | PRO_5016183772 | 157-227 | Hexon-linking protein-C | |||
Sequence: SRSSFNPREELFLKLQSAPSQPRSGGIGSWQFVEEFVPAVYYNPFSGPPGTYPDQFISNYDVVSDSVDGYD |
Post-translational modification
Cleaved by the viral protease during virion maturation. May cause the middle segment to be shed from the capsid.
Keywords
- PTM
Expression
Induction
Expressed in the late phase of the viral replicative cycle.
Keywords
- Developmental stage
Interaction
Subunit
Interacts with the peripentonal hexons as well as the hexons in the facets. Part of a complex composed of the core-capsid bridging protein, the endosome lysis protein VI and the hexon-linking protein VIII; these interactions bridge the virus core to the capsid.
Structure
Sequence
- Sequence statusComplete
- Length227
- Mass (Da)24,847
- Last updated2018-09-12 v1
- ChecksumB35E9B1F1A925F83