A0A2U8XGT3 · A0A2U8XGT3_9BIVA

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processoxidative phosphorylation
Biological Processrespiratory electron transport chain

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Florida_2
    • Florida_3
    • Florida_7
    • Florida_8
    • Haiti_1
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Bivalvia > Autobranchia > Pteriomorphia > Limoida > Limidae > Ctenoides

Accessions

  • Primary accession
    A0A2U8XGT3

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-50Helical
Transmembrane70-97Helical
Transmembrane118-139Helical
Transmembrane151-178Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-182Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    182
  • Mass (Da)
    19,741
  • Last updated
    2018-09-12 v1
  • Checksum
    5221CE8852C87735
FSLVIRMQLSRPGQWLGDSQLYNVVVTSHALLMIFFFVMPVLIGGFGNWLIPLMIGSPDMAFPRLNNLSFWLLVPALFLVLSSMRVGGGSGSGWTLYPPLSGLIGEHSSCVDYTIVSLHLAGLSSMTGAINFLSTIYLSRPDAMVGERLPLYGWSISVTAVLLLVSIPVLAGALTMLLTDRH

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue182

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MF540382
EMBL· GenBank· DDBJ
AWN57546.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540383
EMBL· GenBank· DDBJ
AWN57547.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540384
EMBL· GenBank· DDBJ
AWN57548.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540385
EMBL· GenBank· DDBJ
AWN57549.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540386
EMBL· GenBank· DDBJ
AWN57550.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540387
EMBL· GenBank· DDBJ
AWN57551.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540388
EMBL· GenBank· DDBJ
AWN57552.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540389
EMBL· GenBank· DDBJ
AWN57553.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540390
EMBL· GenBank· DDBJ
AWN57554.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540391
EMBL· GenBank· DDBJ
AWN57555.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540392
EMBL· GenBank· DDBJ
AWN57556.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540393
EMBL· GenBank· DDBJ
AWN57557.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540394
EMBL· GenBank· DDBJ
AWN57558.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540395
EMBL· GenBank· DDBJ
AWN57559.1
EMBL· GenBank· DDBJ
Genomic DNA
MF540397
EMBL· GenBank· DDBJ
AWN57561.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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