A0A2U8T666 · A0A2U8T666_RHIMP

Function

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mg2+ or Mn2+ ion per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, site.

141850100150200250300350400
Type
IDPosition(s)Description
Binding site109-111NADP+ (UniProtKB | ChEBI)
Binding site111D-threo-isocitrate (UniProtKB | ChEBI)
Binding site116NADP+ (UniProtKB | ChEBI)
Binding site128-134D-threo-isocitrate (UniProtKB | ChEBI)
Binding site143D-threo-isocitrate (UniProtKB | ChEBI)
Binding site166D-threo-isocitrate (UniProtKB | ChEBI)
Site173Critical for catalysis
Site246Critical for catalysis
Binding site286Mn2+ (UniProtKB | ChEBI)
Binding site294NADP+ (UniProtKB | ChEBI)
Binding site309Mn2+ (UniProtKB | ChEBI)
Binding site344-349NADP+ (UniProtKB | ChEBI)
Binding site362NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functionisocitrate dehydrogenase (NADP+) activity
Molecular Functionmagnesium ion binding
Molecular FunctionNAD binding
Biological Processglyoxylate cycle
Biological Processisocitrate metabolic process
Biological ProcessNADP metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    isocitrate dehydrogenase (NADP(+))
  • EC number
  • Alternative names
    • NADP(+)-specific ICDH
    • Oxalosuccinate decarboxylase

Organism names

Accessions

  • Primary accession
    A0A2U8T666

Organism-specific databases

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain43-417Isopropylmalate dehydrogenase-like

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    418
  • Mass (Da)
    47,345
  • Last updated
    2018-09-12 v1
  • Checksum
    DF95F66B255D18E5
MARALFKFSRLLQRESVSSSPAAVHVLQSRSYGSEKRIEVQNPVVELDGDEMTRIIWQKIKEELIFPFLKLDCKYYDLGLPSRDKTDDQVTYDAAHAIKKYNVGIKCATITPDEARVEEFNLKKMYPSPNGTIRNILGGTVFREPILCKNIPRLVPGWTQPIVIGRHAFGDQYKAMDRVVSNMGKVELVFTPADGGEKQKHVVFDFKKSGGVTMAMYNTDESIEGFAHSCFQYALMKEWPLYLSTKNTILKQYDGRFKDIFQSIYEKEYKDKFEARKMWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDIIAQGYGSLGLMTSVLVCPDGKTVEAEAAHGTVTRHYREHQKGKKTSTNPIASIFAWTRGLDHRAKLDNNTDLHKFCSALEKACVETVESGKMTKDLAGCIHGIK

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue418

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY953209
EMBL· GenBank· DDBJ
AWM72027.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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