A0A2U8T666 · A0A2U8T666_RHIMP
- Proteinisocitrate dehydrogenase (NADP(+))
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids418 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 1 Mg2+ or Mn2+ ion per subunit.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 109-111 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 111 | D-threo-isocitrate (UniProtKB | ChEBI) | |||
Binding site | 116 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 128-134 | D-threo-isocitrate (UniProtKB | ChEBI) | |||
Binding site | 143 | D-threo-isocitrate (UniProtKB | ChEBI) | |||
Binding site | 166 | D-threo-isocitrate (UniProtKB | ChEBI) | |||
Site | 173 | Critical for catalysis | |||
Site | 246 | Critical for catalysis | |||
Binding site | 286 | Mn2+ (UniProtKB | ChEBI) | |||
Binding site | 294 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 309 | Mn2+ (UniProtKB | ChEBI) | |||
Binding site | 344-349 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 362 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | isocitrate dehydrogenase (NADP+) activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | NAD binding | |
Biological Process | glyoxylate cycle | |
Biological Process | isocitrate metabolic process | |
Biological Process | NADP metabolic process | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameisocitrate dehydrogenase (NADP(+))
- EC number
- Alternative names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Parasitiformes > Ixodida > Ixodoidea > Ixodidae > Rhipicephalinae > Rhipicephalus > Boophilus
Accessions
- Primary accessionA0A2U8T666
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Sequence
- Sequence statusFragment
- Length418
- Mass (Da)47,345
- Last updated2018-09-12 v1
- ChecksumDF95F66B255D18E5
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 418 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KY953209 EMBL· GenBank· DDBJ | AWM72027.1 EMBL· GenBank· DDBJ | mRNA |