A0A2U8I6J5 · A0A2U8I6J5_9GAMM

Function

function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.

Catalytic activity

Features

Showing features for binding site.

145350100150200250300350400450
TypeIDPosition(s)Description
Binding site107-114GTP (UniProtKB | ChEBI)
Binding site190-194GTP (UniProtKB | ChEBI)
Binding site248-251GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentsignal recognition particle
Molecular Function7S RNA binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological ProcessSRP-dependent cotranslational protein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Signal recognition particle protein
  • EC number
  • Alternative names
    • Fifty-four homolog

Gene names

    • Name
      ffh
    • ORF names
      CCS41_10450

Organism names

  • Taxonomic identifier
  • Strain
    • 5D
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Candidatus Fukatsuia

Accessions

  • Primary accession
    A0A2U8I6J5

Proteomes

Subcellular Location

Cytoplasm
Note: The SRP-RNC complex is targeted to the cytoplasmic membrane.

Keywords

Interaction

Subunit

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain269-282SRP54-type proteins GTP-binding

Domain

Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.

Sequence similarities

Belongs to the GTP-binding SRP family. SRP54 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    453
  • Mass (Da)
    49,706
  • Last updated
    2018-09-12 v1
  • Checksum
    7FE9C49DF0198988
MFENLTDRLSGAMRNISGRGRLTEKNIKDALREVHVALLDADVSLSVVQAIISEITKHALGKTVNRGFTPGQELIKIVKRELTSAMGDANSELSLAAQPPAVVLVAGLQGAGKTTSVAKLGKFLKAKHKKKVLVVSADVYRPAAIQQLERLAQEVEIDFYPSHEQEEPIDIVNRALERAEIEFYDVLIVDTAGRLHVDDAMMDEIKKLHTAVNPVETLFVVDAMTGQDAANIATAFNQALPLTGVVLTKVDGDARGGAALSIRHLTGKPIKFLGVGEKTDALKPFYPDRIASRILGMGDVLSLIDDIESTVNQAQAKKMATKLKKGHGFDLNDFQEQLKQMRNMGGVNNMLNKMPGIGQLSGNIKSQMDDKMTVRMEAIINSMTLKERAKPEIIKGSHRRRIASGSGVQVHDVNVLLKQFDDMQRMMKKMKNGGMTKMMRSMRGMMLPGFLGR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP021659
EMBL· GenBank· DDBJ
AWK14796.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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