A0A2U3TAX1 · A0A2U3TAX1_CTEID
- ProteinRho-associated protein kinase
- GeneROCK1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1360 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+This reaction proceeds in the forward direction.
Cofactor
Activity regulation
Activated by RHOA binding. Inhibited by Y-27632.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | bleb | |
Cellular Component | centriole | |
Cellular Component | cytoplasmic stress granule | |
Cellular Component | Golgi membrane | |
Cellular Component | lamellipodium | |
Cellular Component | plasma membrane | |
Cellular Component | ruffle | |
Molecular Function | ATP binding | |
Molecular Function | histone H2AS1 kinase activity | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | Rho-dependent protein serine/threonine kinase activity | |
Molecular Function | small GTPase binding | |
Biological Process | actomyosin structure organization | |
Biological Process | cortical actin cytoskeleton organization | |
Biological Process | embryonic morphogenesis | |
Biological Process | mitotic cytokinesis | |
Biological Process | peptidyl-threonine phosphorylation | |
Biological Process | regulation of cell junction assembly | |
Biological Process | Rho protein signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRho-associated protein kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Xenocyprididae > Xenocypridinae > Ctenopharyngodon
Accessions
- Primary accessionA0A2U3TAX1
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 78-340 | Protein kinase | ||||
Sequence: YEVVKVIGRGAFGEVQLVRHKATRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSNWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDGIHSMGFIHRDVKPDNMLLDKTGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNALTFPDDSDISKDAKSLICAFLTDREVRLGRNGVDEIKRHNFF | ||||||
Domain | 343-411 | AGC-kinase C-terminal | ||||
Sequence: DQWAWENIRETAAPVVPELSSDVDTSNFDDIEEDRGEEETFPIPKAFVGNQLPFVGFTYYSNNQFPRES | ||||||
Coiled coil | 422-470 | |||||
Sequence: TKEDKSQLEDLQKRIYQLEEQLHSEMQLRDEMEQKCRASNTKLDKIMKE | ||||||
Coiled coil | 499-708 | |||||
Sequence: ATEHQRKADQEAEKRRNLENEVSTLKEQLEDLRKISQNNDKIAQLQNQLGEANDLLRAESDTVVRLRKSHTEMAKSVSQLEGVNRELQEKSRAAESIKHQLEKELLQLQTTLDTERRTCSRGSEEIRELQARITGLQEDNKNLKQSLSKVELERKQVQDRCNVLEKEKNSLEIDLNYKLKTLQQRLDQELTEHRITKAQLTDKYESIEES | ||||||
Coiled coil | 748-887 | |||||
Sequence: LKQSVQKMEQLMKQKERLEDEVKDLRVQLEQESGKRVLAQNELKSWTMEAERLKGSEKQLKQEINAALENKRSVEFQLAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRQTQEALKKVQDLYSE | ||||||
Coiled coil | 927-982 | |||||
Sequence: VSRYKQEISEKDSTITQLEESNKTLTKDVEILSKEKTELNERLQAQEGEFAAEKEE | ||||||
Domain | 952-1018 | RhoBD | ||||
Sequence: TKDVEILSKEKTELNERLQAQEGEFAAEKEEVANSVKANYEKALNIERTLKTQAVNKLAEIMNRKDM | ||||||
Region | 1017-1039 | Disordered | ||||
Sequence: DMKLDQKKRGSTTDLRKKEKENR | ||||||
Domain | 1124-1323 | PH | ||||
Sequence: ESRLEGWLAIPNRANIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETDEIPRIFQILYANEGECRKEADVESVPQGDKANCLPHKGHEFIPTLYHFPSNCEACSKPLWHVFKPPPALECRRCHVKCHKDHLDKKEDVIAPCKVNYDVTSARDMLLLALSQDEQKKWIGHLGKKIP | ||||||
Domain | 1234-1289 | Phorbol-ester/DAG-type | ||||
Sequence: GHEFIPTLYHFPSNCEACSKPLWHVFKPPPALECRRCHVKCHKDHLDKKEDVIAPC | ||||||
Region | 1320-1360 | Disordered | ||||
Sequence: KKIPKTPPSTFSRASPRTMSTRSVANQSFRKNPKNLPGKPS | ||||||
Compositional bias | 1327-1353 | Polar residues | ||||
Sequence: PSTFSRASPRTMSTRSVANQSFRKNPK |
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,360
- Mass (Da)158,036
- Last updated2018-07-18 v1
- ChecksumF774B2CAF6744D94
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1327-1353 | Polar residues | ||||
Sequence: PSTFSRASPRTMSTRSVANQSFRKNPK |