A0A2U3TAX1 · A0A2U3TAX1_CTEID

Function

function

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Activated by RHOA binding. Inhibited by Y-27632.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site107ATP (UniProtKB | ChEBI)
Active site200Proton acceptor

GO annotations

AspectTerm
Cellular Componentbleb
Cellular Componentcentriole
Cellular Componentcytoplasmic stress granule
Cellular ComponentGolgi membrane
Cellular Componentlamellipodium
Cellular Componentplasma membrane
Cellular Componentruffle
Molecular FunctionATP binding
Molecular Functionhistone H2AS1 kinase activity
Molecular Functionmetal ion binding
Molecular Functionprotein serine kinase activity
Molecular FunctionRho-dependent protein serine/threonine kinase activity
Molecular Functionsmall GTPase binding
Biological Processactomyosin structure organization
Biological Processcortical actin cytoskeleton organization
Biological Processembryonic morphogenesis
Biological Processmitotic cytokinesis
Biological Processpeptidyl-threonine phosphorylation
Biological Processregulation of cell junction assembly
Biological ProcessRho protein signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Rho-associated protein kinase
  • EC number

Gene names

    • Name
      ROCK1

Organism names

Accessions

  • Primary accession
    A0A2U3TAX1

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias.

TypeIDPosition(s)Description
Domain78-340Protein kinase
Domain343-411AGC-kinase C-terminal
Coiled coil422-470
Coiled coil499-708
Coiled coil748-887
Coiled coil927-982
Domain952-1018RhoBD
Region1017-1039Disordered
Domain1124-1323PH
Domain1234-1289Phorbol-ester/DAG-type
Region1320-1360Disordered
Compositional bias1327-1353Polar residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,360
  • Mass (Da)
    158,036
  • Last updated
    2018-07-18 v1
  • Checksum
    F774B2CAF6744D94
MNMSAGESLTARFEKIDAMLKDPKSEVNTDCLLDSLDALVYDLDFPALRKNKSIDNFLNRYKDTISKIRELRMKAEDYEVVKVIGRGAFGEVQLVRHKATRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSNWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDGIHSMGFIHRDVKPDNMLLDKTGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNALTFPDDSDISKDAKSLICAFLTDREVRLGRNGVDEIKRHNFFKNDQWAWENIRETAAPVVPELSSDVDTSNFDDIEEDRGEEETFPIPKAFVGNQLPFVGFTYYSNNQFPRESTIKTSDKHCSTKEDKSQLEDLQKRIYQLEEQLHSEMQLRDEMEQKCRASNTKLDKIMKELDEECNLRKSVEANMSLLEKDKIMIQHRATEHQRKADQEAEKRRNLENEVSTLKEQLEDLRKISQNNDKIAQLQNQLGEANDLLRAESDTVVRLRKSHTEMAKSVSQLEGVNRELQEKSRAAESIKHQLEKELLQLQTTLDTERRTCSRGSEEIRELQARITGLQEDNKNLKQSLSKVELERKQVQDRCNVLEKEKNSLEIDLNYKLKTLQQRLDQELTEHRITKAQLTDKYESIEESKSAAMHAVEQKVSEETTLRMRAESRVVEVEKQCSMLEFDLKQSVQKMEQLMKQKERLEDEVKDLRVQLEQESGKRVLAQNELKSWTMEAERLKGSEKQLKQEINAALENKRSVEFQLAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRQTQEALKKVQDLYSEKESLSAQLDLTMTKAESEQLARALQEEQYFELSQENKKAVSRYKQEISEKDSTITQLEESNKTLTKDVEILSKEKTELNERLQAQEGEFAAEKEEVANSVKANYEKALNIERTLKTQAVNKLAEIMNRKDMKLDQKKRGSTTDLRKKEKENRKLQLELNQEKEKFNHMAIKYQKELNEMQAQLAEESTYRNELQMQLDSKESDIEQLREKLNDLQLRVDNSSVTSLQTDEMDSNIAESRLEGWLAIPNRANIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETDEIPRIFQILYANEGECRKEADVESVPQGDKANCLPHKGHEFIPTLYHFPSNCEACSKPLWHVFKPPPALECRRCHVKCHKDHLDKKEDVIAPCKVNYDVTSARDMLLLALSQDEQKKWIGHLGKKIPKTPPSTFSRASPRTMSTRSVANQSFRKNPKNLPGKPS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1327-1353Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY780630
EMBL· GenBank· DDBJ
ATU82388.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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