A0A2U1PNI2 · A0A2U1PNI2_ARTAN
- Proteinsignal-recognition-particle GTPase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids859 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA.
Catalytic activity
- GTP + H2O = GDP + phosphate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | signal recognition particle, endoplasmic reticulum targeting | |
Molecular Function | 7S RNA binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | endoplasmic reticulum signal peptide binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | zinc ion binding | |
Biological Process | SRP-dependent cotranslational protein targeting to membrane, translocation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namesignal-recognition-particle GTPase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > campanulids > Asterales > Asteraceae > Asteroideae > Anthemideae > Artemisiinae > Artemisia
Accessions
- Primary accessionA0A2U1PNI2
Proteomes
Subcellular Location
Interaction
Subunit
Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 464-484 | Disordered | ||||
Sequence: MQSNDPGSSGGSSGGHPPTTI | ||||||
Region | 666-755 | Disordered | ||||
Sequence: VKRNYEGEPVQSGQGNGQRGSNARGGDRRGHDYRGYGRSDQGNYRSGRDYQNRDYQRGDQQNRGRHDYRTSGSYGQKGNGDRATSTPCNS | ||||||
Compositional bias | 689-703 | Basic and acidic residues | ||||
Sequence: RGGDRRGHDYRGYGR | ||||||
Compositional bias | 715-731 | Basic and acidic residues | ||||
Sequence: YQNRDYQRGDQQNRGRH | ||||||
Compositional bias | 732-755 | Polar residues | ||||
Sequence: DYRTSGSYGQKGNGDRATSTPCNS | ||||||
Domain | 772-787 | CCHC-type | ||||
Sequence: CFLCGDTRHMARDCPQ | ||||||
Region | 786-818 | Disordered | ||||
Sequence: PQKNGTNNNKGNGGNRQQNSQGRVHSMTRHQAA |
Sequence similarities
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length859
- Mass (Da)96,535
- Last updated2018-07-18 v1
- Checksum77B8DE5495CEC624
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 689-703 | Basic and acidic residues | ||||
Sequence: RGGDRRGHDYRGYGR | ||||||
Compositional bias | 715-731 | Basic and acidic residues | ||||
Sequence: YQNRDYQRGDQQNRGRH | ||||||
Compositional bias | 732-755 | Polar residues | ||||
Sequence: DYRTSGSYGQKGNGDRATSTPCNS |
Keywords
- Technical term