A0A2U1PNI2 · A0A2U1PNI2_ARTAN

Function

function

Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentsignal recognition particle, endoplasmic reticulum targeting
Molecular Function7S RNA binding
Molecular FunctionATP hydrolysis activity
Molecular Functionendoplasmic reticulum signal peptide binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionzinc ion binding
Biological ProcessSRP-dependent cotranslational protein targeting to membrane, translocation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    signal-recognition-particle GTPase
  • EC number

Gene names

    • ORF names
      CTI12_AA132610

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Huhao1
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > campanulids > Asterales > Asteraceae > Asteroideae > Anthemideae > Artemisiinae > Artemisia

Accessions

  • Primary accession
    A0A2U1PNI2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region464-484Disordered
Region666-755Disordered
Compositional bias689-703Basic and acidic residues
Compositional bias715-731Basic and acidic residues
Compositional bias732-755Polar residues
Domain772-787CCHC-type
Region786-818Disordered

Sequence similarities

Belongs to the GTP-binding SRP family. SRP54 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    859
  • Mass (Da)
    96,535
  • Last updated
    2018-07-18 v1
  • Checksum
    77B8DE5495CEC624
MVLQELGGKISSALQQMTNATTVNQKVFDKCLNDIARALLQNDVQVEIVGDLQSNIKRIVNLDGRAEGHNKRKIIQQAVFSELCKMLDPGKPSFTPKKNEPSVVMFVGLQGSGKTTTCTKYAHYYQNKGWKPALVCADTFRAGAFDQLKQNATKANIPFYGSHTESDPVNVAVEGVETFKRENRNLIIIDTSGRHVQEKALFEEMLQLREATKPDLVIFVMDSSIGQAAFKQAQAFKQSVDVGAVIVTKMDGHAKGGGALSAVAATKSPVIFIGTGEHINEFEDFNVKPFVSRLLGIRDLSGFINQVKEVVQVDEQELMQKLLEQNFTMRIMYELFQKILEGSFNQVLSMLMPKEHENESQVKIRRYLTMMDSMTNEELGSTDLKLMKESRIMRIARGAGRQVSEVFEMFQEYKRLTISVSKMKKMVNTRHTDEFTSNPAFEAAVQRRVDAMIPNITARIAERMQSNDPGSSGGSSGGHPPTTITSWLEKFSKEKPKSFSSASSPSEAEDWLGHIEKLLEGLGCGDEFKARLATYKFEGDALNWWKSYKAAKGDDFMTTLTWAGFREIFLLHFFPVSKQEKFEHEYHNIYQYEKETSTEFMKRFLRLAGFMGARAGTQAEQAKKFKWALRNEVLEGIVNTHFDDVAQVANAVRNLEILKERAKQGVKRNYEGEPVQSGQGNGQRGSNARGGDRRGHDYRGYGRSDQGNYRSGRDYQNRDYQRGDQQNRGRHDYRTSGSYGQKGNGDRATSTPCNSCGKTHPGRQCYRAIGACFLCGDTRHMARDCPQKNGTNNNKGNGGNRQQNSQGRVHSMTRHQAANSSEQIDVELCVRGCDCYWASLKVEPNLILRIKEAQKDDDG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias689-703Basic and acidic residues
Compositional bias715-731Basic and acidic residues
Compositional bias732-755Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PKPP01000924
EMBL· GenBank· DDBJ
PWA87328.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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