A0A2T6ISY3 · A0A2T6ISY3_TOXGO
- Proteinproton-translocating NAD(P)(+) transhydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1019 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
- NAD+ + NADPH + H+(in) = NADH + NADP+ + H+(out)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | plasma membrane | |
Molecular Function | NADP binding | |
Molecular Function | oxidoreductase activity | |
Molecular Function | proton-translocating NAD(P)+ transhydrogenase activity | |
Biological Process | NADPH regeneration |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameproton-translocating NAD(P)(+) transhydrogenase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Toxoplasma
Accessions
- Primary accessionA0A2T6ISY3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 29-47 | Helical | ||||
Sequence: GNILGMTGMGAAILITFST | ||||||
Transmembrane | 54-73 | Helical | ||||
Sequence: YAAFFLTIAPPAIVGVYIAQ | ||||||
Transmembrane | 85-105 | Helical | ||||
Sequence: ALFHSFVGLAAVLVGISSFHA | ||||||
Transmembrane | 157-177 | Helical | ||||
Sequence: AINAMTVAAVAVVGITFCATA | ||||||
Transmembrane | 184-207 | Helical | ||||
Sequence: ICLYTLITLSLWLGFHLVASIGGA | ||||||
Transmembrane | 235-255 | Helical | ||||
Sequence: LLIIAGSLIGSSGAILSYIMC | ||||||
Transmembrane | 907-926 | Helical | ||||
Sequence: AFFAMSLVCTAAFAGLLGVT | ||||||
Transmembrane | 932-950 | Helical | ||||
Sequence: LQQFTLLALSLIVGYYSVW | ||||||
Transmembrane | 986-1008 | Helical | ||||
Sequence: ASAICALCATFFSSLNIAGGFYV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MRGFVYLFSAICFILSLRG | ||||||
Chain | PRO_5015754678 | 20-1019 | proton-translocating NAD(P)+ transhydrogenase | |||
Sequence: LSTPETAKRGNILGMTGMGAAILITFSTEGFGGHYAAFFLTIAPPAIVGVYIAQSVSMVQMPQLVALFHSFVGLAAVLVGISSFHAGLGESGTNATRAVETAVGEFVAAVTFTGSLVAAAKLHELMDPKSLKIPGRHAINAMTVAAVAVVGITFCATADTTTKIICLYTLITLSLWLGFHLVASIGGADMPVVISMLNSYSGFATAASGFMLDNNLLIIAGSLIGSSGAILSYIMCRGMNRDLWSVVLGGWEDAPAEGVPGVEGVVREISPDSVAEEVLLAKKVLIVPGYGMAVSRCQSDVADIAQILASRGVEVEFGIHPVAGRMPGHMNVLLAEANVSYRSVKEMSEVNKQMLEYDVVIVVGANDTVNPASLEPGTKIYGMPVIEVWKAKRVIVLKRSLAPGYAAIDNPLFFLDNTRMLFGNAKDTTTAIFACLSQRAAFVGKSAVFLDLEGGARALEEGRRETPPTTWPSPKRTVGVLKDSNGRGTPLVSLAPRFVKRLRKQAFRVIVESGAGAEANFSDDDYVKAGAEIMPNADTVISRSDVILKVSVPSEELIRRIPRGKILISHVFPGQNAPLLELMASQGLTALAVDEVPRITRAQNVDVKSSMQGLQGYRAVLEAFNALPRLSKTSITAAGRVDAARVLVLGAGVAGLQAISTAHGLQAEVFAYDVRAATREEVESCGGTFLSVELEEEGEVEGGYAREMGEAYEMAQKQMLSRVVPNVDVIICTAAIHGKPSPKLISNDMLATMRPGSVVIDLATEFGDRRSNWGGNVEGSPTDGETQIHGVTIIGRSRIETQMPTQASELFSMNMSNLLEELGGGENFRIDLTNEVIKGLCCVHEGRVSWAPPEPLPRRPPTPSPRSSPRLVPPKEVSLLDQLVTSDAFFAMSLVCTAAFAGLLGVTLKALELQQFTLLALSLIVGYYSVWSVTPALHTPLMSVTNALSGVIIIGSMLEYGPSATSASAICALCATFFSSLNIAGGFYVTQRMMQMFQIA |
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 498-634 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal | ||||
Sequence: GVLKDSNGRGTPLVSLAPRFVKRLRKQAFRVIVESGAGAEANFSDDDYVKAGAEIMPNADTVISRSDVILKVSVPSEELIRRIPRGKILISHVFPGQNAPLLELMASQGLTALAVDEVPRITRAQNVDVKSSMQGLQ | ||||||
Domain | 643-814 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding | ||||
Sequence: FNALPRLSKTSITAAGRVDAARVLVLGAGVAGLQAISTAHGLQAEVFAYDVRAATREEVESCGGTFLSVELEEEGEVEGGYAREMGEAYEMAQKQMLSRVVPNVDVIICTAAIHGKPSPKLISNDMLATMRPGSVVIDLATEFGDRRSNWGGNVEGSPTDGETQIHGVTIIG | ||||||
Region | 870-891 | Disordered | ||||
Sequence: APPEPLPRRPPTPSPRSSPRLV | ||||||
Compositional bias | 872-889 | Pro residues | ||||
Sequence: PEPLPRRPPTPSPRSSPR |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,019
- Mass (Da)108,282
- Last updated2018-07-18 v1
- Checksum3C6DEA71A6D0CDEB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 872-889 | Pro residues | ||||
Sequence: PEPLPRRPPTPSPRSSPR |