A0A2T6INB6 · A0A2T6INB6_TOXGO

Function

function

Serine protease involved in intramembrane proteolysis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.
    EC:3.4.21.105 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

164050100150200250300350400450500550600
TypeIDPosition(s)Description
Active site531Nucleophile
Active site585

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionserine-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Rhomboid-like protease
  • EC number

Gene names

    • ORF names
      TGBR9_294690A

Organism names

  • Taxonomic identifier
  • Strain
    • TgCATBr9
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Toxoplasma

Accessions

  • Primary accession
    A0A2T6INB6

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane323-343Helical
Transmembrane467-485Helical
Transmembrane497-517Helical
Transmembrane524-546Helical
Transmembrane552-571Helical
Transmembrane583-600Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-289Disordered
Compositional bias10-57Basic and acidic residues
Compositional bias80-136Polar residues
Compositional bias192-206Polar residues
Compositional bias209-229Basic and acidic residues
Compositional bias247-272Basic and acidic residues
Domain462-601Peptidase S54 rhomboid

Sequence similarities

Belongs to the peptidase S54 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    640
  • Mass (Da)
    69,909
  • Last updated
    2018-07-18 v1
  • Checksum
    08355EE4F43D9AF3
MSSKGGSSRLGSKDLKKMTSRTERELRDSGRVRGEVERVEKRLRATAKVKEQPPTGDYKRRALASPGETAAPTFLVDSRGIPRKTSSTAPRKATLRPASSSPRLASSSRPTESTLPSSSSRALQGASSSSSSRPRRLHESASGRGGSGGSAGELRQEKKRLPELEAAEAAPASCVVELRDVTARKGRTSPATPPETAGSSVCGQGSHARTAEKLEEGTASHRDGSRRGSVDAETWATPGDGSSSHEFESSPQREERMQPQETGRRELSSEPRSGDLTKNGGDGGPRRHSCAWRKWREHMIQSFDITTHPFPPRGDGSPRRGKFLMIFLTSSVLFFVFLQELVLNVTTFNGRCMSPVLYPSHDAPESERTPRVISFGYGACEHNLGVSLFRREETKKDPRGRWTPGPLTERCASGRCASDDGWPSDLVQRGRAQRSPAAFDSPNPRVFSSLGALDTNKVRNYGEMFRVVWGMFLHGGWMHLLLNVSCQAQTLWILEPAWGFLRTLSLWIVGGVSGSLLSAVANPCTVTVGSSGAFYGLLGALVPFSIEYWDHIASPAWFLFCVSVLVMVAQFGNMVGVQGVDNNAHLGGLIGGLLFGFATIRSVHAFRWQGVAERMASSTLFWWMFPAEKRRSLREDNLQR

Features

Showing features for compositional bias, non-terminal residue.

Type
IDPosition(s)Description
Compositional bias10-57Basic and acidic residues
Compositional bias80-136Polar residues
Compositional bias192-206Polar residues
Compositional bias209-229Basic and acidic residues
Compositional bias247-272Basic and acidic residues
Non-terminal residue640

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AFHV02002277
EMBL· GenBank· DDBJ
PUA86811.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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