A0A2T6IK68 · A0A2T6IK68_TOXGO
- ProteinInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids689 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Catalytic activity
- 1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | diphosphoinositol-pentakisphosphate kinase activity | |
Molecular Function | inositol heptakisphosphate kinase activity | |
Molecular Function | inositol hexakisphosphate 1-kinase activity | |
Molecular Function | inositol hexakisphosphate 3-kinase activity | |
Molecular Function | inositol hexakisphosphate 5-kinase activity | |
Molecular Function | inositol-1,3,4,5,6-pentakisphosphate kinase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Toxoplasma
Accessions
- Primary accessionA0A2T6IK68
Proteomes
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 76-134 | Polar residues | ||||
Sequence: CAQGAGTSASGSSDPRGGPPRSTDPTETFVTGSNTELQLVAASPPSASSASFASPSPLF | ||||||
Region | 76-139 | Disordered | ||||
Sequence: CAQGAGTSASGSSDPRGGPPRSTDPTETFVTGSNTELQLVAASPPSASSASFASPSPLFRASSP | ||||||
Region | 166-341 | Disordered | ||||
Sequence: EEEKRRERQTAEADLRLPAAAASSGGSSPEGVLGGRALLEDEKQFRREGGKTGGDPASAAESQDVCRSRKETGEQRKEHKRTPSSGSSPLCLAGLPSRETRMHAPAVGSEETVAAREARRGFGVGEDSPQDGALSPSFSSFSVSHAPLETDPPEDRAGTMSPYTTAGEASGDDDEE | ||||||
Compositional bias | 201-215 | Basic and acidic residues | ||||
Sequence: RALLEDEKQFRREGG | ||||||
Compositional bias | 229-248 | Basic and acidic residues | ||||
Sequence: DVCRSRKETGEQRKEHKRTP | ||||||
Compositional bias | 297-311 | Polar residues | ||||
Sequence: GALSPSFSSFSVSHA | ||||||
Region | 427-480 | Disordered | ||||
Sequence: EARAASPSPSASCSACASPDSASAEASDPGASGHVSSGGAGEEDSVGLTREAQG | ||||||
Compositional bias | 433-447 | Polar residues | ||||
Sequence: PSPSASCSACASPDS | ||||||
Region | 527-652 | Disordered | ||||
Sequence: IEWEETGSPRVASSHVSTASSASSSSSSSSSSSCASSSESTSASASSSSSASPSVLSGEARVGVGGHCGEAGMQSSAKGKGEKTKPRGASGQMPVESATSSSASPAPPSPPPLSSSGAAGTAAGPP | ||||||
Compositional bias | 536-582 | Polar residues | ||||
Sequence: RVASSHVSTASSASSSSSSSSSSSCASSSESTSASASSSSSASPSVL |
Sequence similarities
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Family and domain databases
Sequence
- Sequence statusFragment
- Length689
- Mass (Da)72,020
- Last updated2018-07-18 v1
- Checksum9DACD6B4DCEAC310
Features
Showing features for compositional bias, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 76-134 | Polar residues | ||||
Sequence: CAQGAGTSASGSSDPRGGPPRSTDPTETFVTGSNTELQLVAASPPSASSASFASPSPLF | ||||||
Compositional bias | 201-215 | Basic and acidic residues | ||||
Sequence: RALLEDEKQFRREGG | ||||||
Compositional bias | 229-248 | Basic and acidic residues | ||||
Sequence: DVCRSRKETGEQRKEHKRTP | ||||||
Compositional bias | 297-311 | Polar residues | ||||
Sequence: GALSPSFSSFSVSHA | ||||||
Compositional bias | 433-447 | Polar residues | ||||
Sequence: PSPSASCSACASPDS | ||||||
Compositional bias | 536-582 | Polar residues | ||||
Sequence: RVASSHVSTASSASSSSSSSSSSSCASSSESTSASASSSSSASPSVL | ||||||
Non-terminal residue | 689 | |||||
Sequence: P |