A0A2T6IFW3 · A0A2T6IFW3_TOXGO
- ProteinATP-dependent (S)-NAD(P)H-hydrate dehydratase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids508 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalytic activity
- (6S)-NADHX + ATP = ADP + H+ + NADH + phosphate
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 137 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 221-227 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: NRREFEL | ||||||
Binding site | 346-350 | ATP (UniProtKB | ChEBI) | ||||
Sequence: KGPAD | ||||||
Binding site | 384-393 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GSPKRSGGQG | ||||||
Binding site | 394 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | ATP-dependent NAD(P)H-hydrate dehydratase activity | |
Molecular Function | kinase activity | |
Biological Process | metabolite repair | |
Biological Process | nicotinamide nucleotide metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent (S)-NAD(P)H-hydrate dehydratase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Toxoplasma
Accessions
- Primary accessionA0A2T6IFW3
Proteomes
Organism-specific databases
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 25-505 | YjeF C-terminal | ||||
Sequence: VKAAKDFFIPPLDFSHHKGQNGRICVVGGALEFTGAPYFSAMAALHMGMDLAYIITTPEAAGPIKTYSPELIVYPILPGQLQSGQSLEDALVRLENKAGEILKKCHVVVMGPGMGAPAMTTPPADEETKGDACGASGANPESGCTIQRAALTVLEVAMKENKFVVIDADMIRVLCTPPHSPSLQRLKNYRRCLLTPNRREFELLQGAFDSLEKPCSPLSNKYFLSSFFQAVQREQQRSCDAPKSENVFADFSRRWQPPPETDPSLAVDSDDVTHANRSPSPPSVAPCPSLIFLDLFPSSLKSFAGRLADLTLGLNGPNLLVKGPADVFVVFSRLPARSEQVCPDARAALATCGLTQNSRGSPKRSGGQGDVLGGILAAFVAWWQIAAEARNRHGGLKAAAGRLSGSACERTPKNEMAHAEGERLSGLVLSGVDEEAAGLLCVMFNASLMVRQTAARAFEEHGRSMLAGHLLPLIGPVFRSL | ||||||
Region | 276-307 | Disordered | ||||
Sequence: SRRWQPPPETDPSLAVDSDDVTHANRSPSPPS |
Sequence similarities
Belongs to the NnrD/CARKD family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length508
- Mass (Da)54,609
- Last updated2018-07-18 v1
- Checksum5D5667838D5FCB40