A0A2T6IFW3 · A0A2T6IFW3_TOXGO

  • Protein
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site137(6S)-NADPHX (UniProtKB | ChEBI)
Binding site221-227(6S)-NADPHX (UniProtKB | ChEBI)
Binding site346-350ATP (UniProtKB | ChEBI)
Binding site384-393ATP (UniProtKB | ChEBI)
Binding site394(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionATP-dependent NAD(P)H-hydrate dehydratase activity
Molecular Functionkinase activity
Biological Processmetabolite repair
Biological Processnicotinamide nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ATP-dependent NAD(P)HX dehydratase

Gene names

    • ORF names
      TGBR9_258160

Organism names

  • Taxonomic identifier
  • Strain
    • TgCATBr9
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Toxoplasma

Accessions

  • Primary accession
    A0A2T6IFW3

Proteomes

Organism-specific databases

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain25-505YjeF C-terminal
Region276-307Disordered

Sequence similarities

Belongs to the NnrD/CARKD family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    508
  • Mass (Da)
    54,609
  • Last updated
    2018-07-18 v1
  • Checksum
    5D5667838D5FCB40
MAENVRSHGEKDNPEAWDETSSAWVKAAKDFFIPPLDFSHHKGQNGRICVVGGALEFTGAPYFSAMAALHMGMDLAYIITTPEAAGPIKTYSPELIVYPILPGQLQSGQSLEDALVRLENKAGEILKKCHVVVMGPGMGAPAMTTPPADEETKGDACGASGANPESGCTIQRAALTVLEVAMKENKFVVIDADMIRVLCTPPHSPSLQRLKNYRRCLLTPNRREFELLQGAFDSLEKPCSPLSNKYFLSSFFQAVQREQQRSCDAPKSENVFADFSRRWQPPPETDPSLAVDSDDVTHANRSPSPPSVAPCPSLIFLDLFPSSLKSFAGRLADLTLGLNGPNLLVKGPADVFVVFSRLPARSEQVCPDARAALATCGLTQNSRGSPKRSGGQGDVLGGILAAFVAWWQIAAEARNRHGGLKAAAGRLSGSACERTPKNEMAHAEGERLSGLVLSGVDEEAAGLLCVMFNASLMVRQTAARAFEEHGRSMLAGHLLPLIGPVFRSLYIE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AFHV02003280
EMBL· GenBank· DDBJ
PUA84234.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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