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A0A2T5Q4A2 · A0A2T5Q4A2_LIMRT

Function

function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Features

Showing features for site, active site.

1821100200300400500600700800
Type
IDPosition(s)Description
Site40Interaction with DNA
Site76Interaction with DNA
Site78Interaction with DNA
Site89Interaction with DNA
Site95Interaction with DNA
Site119Transition state stabilizer
Active site120O-(5'-phospho-DNA)-tyrosine intermediate

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentcytoplasm
Cellular ComponentDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
Cellular Componentextrinsic component of plasma membrane
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Biological Processchromosome segregation
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 4 subunit A
  • EC number
  • Alternative names
    • Topoisomerase IV subunit A

Gene names

    • Name
      parC
    • ORF names
      DB325_04515

Organism names

Accessions

  • Primary accession
    A0A2T5Q4A2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterotetramer composed of ParC and ParE.

Family & Domains

Features

Showing features for domain, coiled coil.

Type
IDPosition(s)Description
Domain9-462DNA topoisomerase type IIA
Coiled coil427-475

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    821
  • Mass (Da)
    92,729
  • Last updated
    2018-07-18 v1
  • MD5 Checksum
    9FAB4F104CEF564F204926B27F9F8B6A
MRNGKIEHMTLEQIMGDRFGRYSKSIIQERALPDIRDGLKPVQRRILFAMNKDGNTYDKGFRKSAKSVGNVMGNFHPHGDSSIYEALVRLSQDWKLREPLIEMHGNNGSMDGDPPAAMRYTEARLSKIAGLMLQDIDKDTVEMALNFDDTEKEPTVLPARIPNLLVNGATGISAGYATEIPTHNLSEVLDALIYLIKHPTASLDKLMEFIPGPDFPTGGIIQGIDGIRKAYQTGRGRVVVRAKTEIETLRGGRQQINVTEIPYEVNKAQLVKRINDLRLAKKVEGIAEARDETDRSGLRIAIELKRGANANGILNYLLKNTDLQINYNFNMVAIDDQRPMRVGLKRILTSYLEFQKEIIRRRTQYNLTKAQQRLHIVEGLIKALSILDKVIKTIRASKNRKDAKENLVKEYNFTPEQAEAIVTLQLYRLTNTDVTELEKEQEQLNSRINEYQLILTNENELAKVLTKEIRAIKKEFGNPRRTKIENHVEKLEIDTKVTVANEDVMVLVSHAGYIKRSSIRSFKASEAEENGLREDDYPLLIQQTNTLSHLFMFTNLGHIIYRPIHEIADARWKDTGEHISQTIGLADNEEIIKAMIFDKLDQPGTIIMGTSDGQVKQTAFNDYKPGSRYKSHASVAIKLRDNAQVVNVDYYEPTNENCSLLTISRQGYAVRYDVADVPVTGIRTAGVRAINLKDDDQVADQTLVKDGQNIAVITQRGAFKAMPVDEIEVGARARRGELVLRRLKSHPHEIADFLAYDPDYQGAFETITNRPAFQDIMATDHHLSSIKSNGTFVIDTDTQGEPVKLRMKQTNILTEEPVSQS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QAZN01000005
EMBL· GenBank· DDBJ
PTV04310.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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