A0A2T5Q4A2 · A0A2T5Q4A2_LIMRT
- ProteinDNA topoisomerase 4 subunit A
- GeneparC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids821 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 40 | Interaction with DNA | |||
Site | 76 | Interaction with DNA | |||
Site | 78 | Interaction with DNA | |||
Site | 89 | Interaction with DNA | |||
Site | 95 | Interaction with DNA | |||
Site | 119 | Transition state stabilizer | |||
Active site | 120 | O-(5'-phospho-DNA)-tyrosine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex | |
Cellular Component | extrinsic component of plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Biological Process | chromosome segregation | |
Biological Process | DNA topological change |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 4 subunit A
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Limosilactobacillus
Accessions
- Primary accessionA0A2T5Q4A2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Heterotetramer composed of ParC and ParE.
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 9-462 | DNA topoisomerase type IIA | |||
Coiled coil | 427-475 | ||||
Sequence similarities
Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length821
- Mass (Da)92,729
- Last updated2018-07-18 v1
- MD5 Checksum9FAB4F104CEF564F204926B27F9F8B6A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
QAZN01000005 EMBL· GenBank· DDBJ | PTV04310.1 EMBL· GenBank· DDBJ | Genomic DNA |