A0A2T5NJP7 · A0A2T5NJP7_9NEIS

Function

function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site21substrate
Binding site43substrate
Active site70For OMPdecase activity
Binding site70-79substrate
Active site72For OMPdecase activity
Active site72Proton donor
Active site75For OMPdecase activity
Binding site129substrate
Binding site190substrate
Binding site199substrate
Binding site219substrate
Binding site220substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionorotidine-5'-phosphate decarboxylase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotidine 5'-phosphate decarboxylase
  • EC number
  • Alternative names
    • OMP decarboxylase
      (OMPDCase
      ; OMPdecase
      )

Gene names

    • Name
      pyrF
    • ORF names
      DB032_12185

Organism names

  • Taxonomic identifier
  • Strain
    • Panama
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Chromobacteriaceae > Chromobacterium

Accessions

  • Primary accession
    A0A2T5NJP7

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-235Orotidine 5'-phosphate decarboxylase

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    245
  • Mass (Da)
    26,026
  • Last updated
    2018-07-18 v1
  • Checksum
    69F3AB5F0983D3DF
MNPLIAADAAQPTSPVVVALDFADADSALRFASRLDPSECRLKVGKELFTSSGRSLVESLVARGFQVFLDLKFHDIPNTVAHACKAAAEAGVWMVNVHASGGRRMMEAAREALAPYSQRPLLIAVTVLTSMEAADLAEIGIAASPQEHVLRLAALTRDCGLDGVVCSAQEAGELKAALGREFKLVTPGIRLADSVADDQRRVMTPTTALAAGSDYLVIGRPITRAADPLAVLRAINQDIQHYQAQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QARX01000001
EMBL· GenBank· DDBJ
PTU65641.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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