A0A2T5IF97 · A0A2T5IF97_9PROT
- ProteinGlycerol-3-phosphate dehydrogenase [NAD(P)+]
- GenegpsA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids333 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.
Catalytic activity
- sn-glycerol 3-phosphate + NAD+ = dihydroxyacetone phosphate + NADH + H+
Pathway
Membrane lipid metabolism; glycerophospholipid metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 7-12 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 10 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 11 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 34 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 35 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 51 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 107 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 107 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 107 | substrate | |||
Binding site | 136 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 138 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 140 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 140 | NADPH (UniProtKB | ChEBI) | |||
Active site | 191 | Proton acceptor | |||
Binding site | 191 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 244 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 254 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 255 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 255 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 255 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 255-256 | substrate | |||
Binding site | 256 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 279 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 281 | NADPH (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | glycerol-3-phosphate dehydrogenase [NAD(P)+] activity | |
Molecular Function | NAD binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | glycerol-3-phosphate biosynthetic process | |
Biological Process | glycerol-3-phosphate catabolic process | |
Biological Process | glycerophospholipid metabolic process | |
Biological Process | phospholipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycerol-3-phosphate dehydrogenase [NAD(P)+]
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Nitrosomonadales > Nitrosomonadaceae > Nitrosospira
Accessions
- Primary accessionA0A2T5IF97
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-16 | ||||
Chain | PRO_5015600562 | 17-333 | Glycerol-3-phosphate dehydrogenase [NAD(P)+] | ||
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 3-160 | Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal | |||
Domain | 180-320 | Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal | |||
Sequence similarities
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length333
- Mass (Da)35,264
- Last updated2018-07-18 v1
- MD5 Checksum50198626F723B41B8BBCC86926E62C7B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
QAOK01000004 EMBL· GenBank· DDBJ | PTQ82500.1 EMBL· GenBank· DDBJ | Genomic DNA |