A0A2T5IF97 · A0A2T5IF97_9PROT

  • Protein
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • Gene
    gpsA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site7-12NAD+ (UniProtKB | ChEBI)
Binding site10NADPH (UniProtKB | ChEBI)
Binding site11NADPH (UniProtKB | ChEBI)
Binding site34NADPH (UniProtKB | ChEBI)
Binding site35NADPH (UniProtKB | ChEBI)
Binding site51NADPH (UniProtKB | ChEBI)
Binding site107NADPH (UniProtKB | ChEBI)
Binding site107sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site107substrate
Binding site136sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site138sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site140NAD+ (UniProtKB | ChEBI)
Binding site140NADPH (UniProtKB | ChEBI)
Active site191Proton acceptor
Binding site191sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site244sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site254sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site255NAD+ (UniProtKB | ChEBI)
Binding site255NADPH (UniProtKB | ChEBI)
Binding site255sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site255-256substrate
Binding site256sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site279NADPH (UniProtKB | ChEBI)
Binding site281NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      C8R21_10443

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Nl12
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Nitrosomonadales > Nitrosomonadaceae > Nitrosospira

Accessions

  • Primary accession
    A0A2T5IF97

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-16
ChainPRO_501560056217-333Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-160Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain180-320Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    333
  • Mass (Da)
    35,264
  • Last updated
    2018-07-18 v1
  • MD5 Checksum
    50198626F723B41B8BBCC86926E62C7B
MRIAVMGAGSWGTALALSLCASTASSHQVTLWTRRRQHLADLVSQRINRRYFPAFPLPASLRLTAELKEAVEDADLALIVVPVSGLRETLREIAASGKKVPVIWGCKGFESQSAKLPHQVAEEEYAGEAPYGVLSGPSFALEVAQGLPAALTLASEDGEFAREVAAQLHTPRLRVYSCTDVVGVETGGAVKNVISIAAGICDGMGFGYNARAALITRGLAEITRLGLKLGGRMETFLGLTGVGDLILTCTGDLSRNRRVGLALAAGRSLPDILQELGHIAEGVQTAREVLRLSHLMGIEMPITKGVCSILDDGVPAGQAVEALLSREPKSEIY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QAOK01000004
EMBL· GenBank· DDBJ
PTQ82500.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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