A0A2T5I8D4 · A0A2T5I8D4_9PROT

Function

function

Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Bacterial outer membrane biogenesis; LPS core biosynthesis.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site204-207ATP (UniProtKB | ChEBI)
Active site279

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionheptose 7-phosphate kinase activity
Molecular Functionheptose-1-phosphate adenylyltransferase activity
Molecular Functionphosphotransferase activity, alcohol group as acceptor
Biological ProcessADP-L-glycero-beta-D-manno-heptose biosynthetic process
Biological Processlipopolysaccharide core region biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein HldE

Including 2 domains:

  • Recommended name
    D-beta-D-heptose 7-phosphate kinase
  • EC number
  • Alternative names
    • D-beta-D-heptose 7-phosphotransferase
    • D-glycero-beta-D-manno-heptose-7-phosphate kinase
  • Recommended name
    D-beta-D-heptose 1-phosphate adenylyltransferase
  • EC number
  • Alternative names
    • D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase

Gene names

    • Name
      hldE
    • ORF names
      C8R21_11914

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Nl12
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Nitrosomonadales > Nitrosomonadaceae > Nitrosospira

Accessions

  • Primary accession
    A0A2T5I8D4

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-332Ribokinase
Domain16-320Carbohydrate kinase PfkB
Domain356-461Cytidyltransferase-like
Region356-491Cytidylyltransferase

Sequence similarities

In the C-terminal section; belongs to the cytidylyltransferase family.
In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    491
  • Mass (Da)
    53,733
  • Last updated
    2018-07-18 v1
  • Checksum
    92507CE74897C1A8
MNSSYLATIDRFSGLNVLVIGDAMLDVYLDGSANRICREAPVPIVDIRDVKAVPGGAANTAVNLAQLGARVHYLSVVGCDHEAELLKESLVSHSLDISLVICDPTRRTLTKQRVAAGAQLLVRFDAGTTEQVCNQHEQQMIDTLNEKFHEMDAVVVSDYGYGILTDPVIDALRVLQKKKENTLVIDAKSLDKYSRLGATVAKPNYQELVTLLAITEPAPVGQRSEQIRLHGQKLLKKSGTKYVAATIDVEGALLFQHGKEPYRTFSKPVENTRAAGAGDTYVSALTLALASGASIEVAGEIAKSAAMVILQKSHTATCTQNELRHYLGSSSKYIADWQGLNNRLATFRKEGKRIVFTNGCFDLLHSGHVSYLEQARDLGDILVLGLNSDASIKRLKGSNRPINNLYERIRILSGLESVTFMTSFEEDTPIDLLQVVQPDLYVKGGDYTIETLPEAPVVRAYGGKVEIMPFVQDRSTTNIISRIKSMDKQVA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QAOK01000019
EMBL· GenBank· DDBJ
PTQ80077.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp