A0A2T4WQ59 · A0A2T4WQ59_UNCBA

  • Protein
    Phosphoribosylglycinamide formyltransferase
  • Gene
    purN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site12-14N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site101(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site103Proton donor
Site144Raises pKa of active site His

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • ORF names
      DA405_02290

Organism names

Accessions

  • Primary accession
    A0A2T4WQ59

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-181Formyl transferase N-terminal

Sequence similarities

Belongs to the GART family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    188
  • Mass (Da)
    21,068
  • Last updated
    2018-07-18 v1
  • MD5 Checksum
    E8880AAA924F9DBF62175D92AE77907C
MKKIVILASGSGTNAENIVRYFEDSDLARVDAIITNNAKAGVIDKARKLGVSCFVIGNQMVAEGDLAKKLTSLKPDLIVLAGYLMLIPQDIISTFPKRIINIHPALLPDYGGAGMYGKYVHQAVVENEEEVSGISIHYVSEAYDEGEIIFQEEVEIDFEDEWQDVEYKIRELEYKHYPAVIEYLLPDL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PZPB01000007
EMBL· GenBank· DDBJ
PTM05904.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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